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  2. RCOR1 - REST corepressor 1 Gene

RCOR1 - REST corepressor 1 Gene

中文名称:REST 核心阻遏物 1

种属: Homo sapiens

同用名: RCOR; COREST

基因 ID: 23186 | 基因类型: protein coding

关于 RCOR1

Cytogenetic location: 14q32.31-q32.32 Genomic coordinates (GRCh38): 14:102,592,649-102,730,561 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.5), esophagus (RPKM 14.2) and 25 other tissues.

功能概要

该基因编码的蛋白质非常保守,出生时下调,在决定神经细胞分化方面具有特定作用。编码的蛋白质与 REST (阻遏物元件 1 沉默转录因子) 的 C 末端结构域结合。[RefSeq 提供,2011 年 8 月]

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

RCOR1 基因产物(1)

mRNA Protein Name
NM_015156.4 NP_055971.2 REST corepressor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10449787 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10449787 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of DNA repair complex IDA
IDA: 通过直接分析推断
24217620 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10734093 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
10734093 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RCOR1 蛋白结构

ELM2

ELM2: ELM2 domain (102 - 156)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (382 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
蛋白主名 其他名称

REST corepressor 1

RCOR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RCOR1 Q9UKL0 ZNF516 Homo sapiens Q92618
Anti Tag CoIP
33961781
种属内
RCOR1 Q9UKL0 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
12192000
种属内
RCOR1 Q9UKL0 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
17939992
种属内
RCOR1 Q9UKL0 SMARCE1 Homo sapiens Q969G3-2
Y2H
12192000
种属内
RCOR1 Q9UKL0 KDM1A Homo sapiens O60341
Anti Tag CoIP
33961781
种属内
RCOR1 Q9UKL0 KDM1A Homo sapiens O60341
Anti Bait CoIP
19703393
种属间: 跨种属相互作用 种属内: 同种属相互作用

RCOR1 抗体

目录号 产品名 应用 反应物种
HY-P82068 CoREST Antibody (YA1813) WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RCOR1 VGNC VGNC:45446
Rattus norvegicus RCOR1 RGD RGD:7505493
Mus musculus RCOR1 MGD MGI:106340
Bos taurus RCOR1 VGNC VGNC:33834
Macaca mulatta RCOR1 VGNC VGNC:76752
Felis catus RCOR1 VGNC VGNC:64551