FLT3LG - fms related receptor tyrosine kinase 3 ligand Gene

中文名称：fms 相关受体酪氨酸激酶 3 配体

种属: Homo sapiens

同用名: FL; FLG3L; FLT3L

基因 ID: 2323 | 基因类型: protein coding

关于 FLT3LG

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,474,215-49,486,231 (from NCBI)

This gene has 12 transcripts (splice variants) and 87 orthologues. Ubiquitous expression in spleen (RPKM 4.5), lymph node (RPKM 4.2) and 24 other tissues.

功能概要

树突状细胞 (DC) 通过识别病原体和引发病原体特异性免疫反应，在先天免疫和适应性免疫之间建立关键联系。 FLT3LG 控制 DC 的发育，对浆细胞样 DC 和 CD8 (参见 MIM 186910) 阳性经典 DC 及其 CD103 (ITGAE；MIM 604682) 阳性组织对应物尤为重要 (Sathaliyawala 等人总结，2010 [PubMed 20933441] ) .[OMIM 提供，2011 年 1 月]

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

FLT3LG 基因产物(5)

mRNA	Protein	Name
NM_001204502.2	NP_001191431.1	fms-related tyrosine kinase 3 ligand isoform 1 precursor
NM_001204503.2	NP_001191432.1	fms-related tyrosine kinase 3 ligand isoform 1 precursor
NM_001278637.2	NP_001265566.1	fms-related tyrosine kinase 3 ligand isoform 2
NM_001278638.2	NP_001265567.1	fms-related tyrosine kinase 3 ligand isoform 2
NM_001459.4	NP_001450.2	fms-related tyrosine kinase 3 ligand isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in embryonic hemopoiesis	IDA IDA: 通过直接分析推断	21149635	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	8180375	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FLT3LG 蛋白结构

Flt3_lig

0
100
200
235 a.a.

蛋白主名

其他名称

fms-related tyrosine kinase 3 ligand

flt3 ligand

FLT3LG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FLT3LG	P49771	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
种属内	FLT3LG	P49771	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FLT3LG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7111	FLT3LG Protein, Human (CHO)	P49771-1 (T27-P185)	≥95%
HY-P70544	FLT3LG Protein, Human (HEK293, His)	P49771-1 (T27-P184)	≥95%
HY-P73066	FLT3LG Protein, Human (sf9, His)	P49771-1 (T27-P185)	≥95%
HY-P70544G	GMP FLT3LG Protein, Human (HEK293, His)	P49771-1 (T27-P184)	≥95%
HY-P700072AF	Animal-Free FLT3LG Protein, Human (His)	P49771-1 (T27-A181)	≥95%

关联疾病

疾病名称

别名

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Epiphyseal Dysplasia, Multiple, 3

EDM3	Multiple Epiphyseal Dysplasia 3
Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy	Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy
Epiphyseal Dysplasia Multiple 3	Dysplasia, Epiphyseal, Multiple, Type 3

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Duodenum Adenoma

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Dendritic Cell Deficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04993	FLT3LG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FLT3LG	VGNC	VGNC:40909
Macaca mulatta	FLT3LG	VGNC	VGNC:72680
Felis catus	FLT3LG	VGNC	VGNC:62300
Bos taurus	FLT3LG	VGNC	VGNC:29043
Rattus norvegicus	FLT3LG	RGD	RGD:2322792
Mus musculus	FLT3LG	MGD	MGI:95560
Susscrofa domestica	FLT3LG	NCBI
Others	FLT3LG	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FLT3LG - fms related receptor tyrosine kinase 3 ligand Gene

关于 FLT3LG

功能概要

FLT3LG 基因产物(5)

FLT3LG 蛋白结构

FLT3LG 蛋白互作信息

重组 FLT3LG 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

FLT3LG - fms related receptor tyrosine kinase 3 ligand Gene

关于 FLT3LG

功能概要

FLT3LG 基因产物(5)

FLT3LG 蛋白结构

FLT3LG 蛋白互作信息

重组 FLT3LG 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z