2. Gene
  3. SCFD1 - sec1 family domain containing 1 Gene

SCFD1 - sec1 family domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 sec1 家族域 1

种属: Homo sapiens

同用名: SLY1; RA410; SLY1P; STXBP1L2; C14orf163

基因 ID: 23256 | 基因类型: protein coding

关于 SCFD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,622,254-30,735,850 (from NCBI)

This gene has 72 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 19.4), testis (RPKM 13.5) and 25 other tissues.

功能概要

预测启用突触融合蛋白结合活动。参与自噬体组装的负调控；调节蛋白质运输；和对有毒物质的反应。位于顺式高尔基体网络中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

SCFD1 基因产物(6)

mRNA Protein Name
NM_001257376.1 NP_001244305.1 sec1 family domain-containing protein 1 isoform c
NM_001283031.1 NP_001269960.1 sec1 family domain-containing protein 1 isoform d
NM_001283032.1 NP_001269961.1 sec1 family domain-containing protein 1 isoform e
NM_001283033.1 NP_001269962.1 sec1 family domain-containing protein 1 isoform d
NM_016106.4 NP_057190.2 sec1 family domain-containing protein 1 isoform a
NM_182835.2 NP_878255.1 sec1 family domain-containing protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19536132 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
21242315 GOA
involved in regulation of protein transport IMP
IMP: 通过突变表型推断
21242315 GOA
involved in response to toxic substance IEP
IEP: 通过表达模式推断
15649705 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cis-Golgi network IDA
IDA: 通过直接分析推断
15649705 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCFD1 蛋白结构

Sec1

Sec1: Sec1 family (43 - 636)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
蛋白主名 其他名称

sec1 family domain-containing protein 1

syntaxin-binding protein 1-like 2

SCFD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCFD1 Q8WVM8 COG4 Homo sapiens Q9H9E3
Pull Down
19536132
Intra SCFD1 Q8WVM8 COG4 Homo sapiens Q9H9E3
Anti Tag CoIP
19536132
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Familial Adenomatous Polyposis 3

FAP3

Nthl1-Related Attenuated Familial Adenomatous Polyposis

Nthl1-Related Afap

Nthl1-Related Attenuated Fap
Achondrogenesis, Type Ia

Achondrogenesis Type Ia

Achondrogenesis Type 1a

ACG1A

Achondrogenesis, Houston-Harris Type

Achondrogenesis Houston-Harris Type

Achondrogenesis 1a

Acg-Ia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12499 SCFD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SCFD1 VGNC VGNC:64907
Rattus norvegicus SCFD1 RGD RGD:619828
Bos taurus SCFD1 VGNC VGNC:34330
Mus musculus SCFD1 MGD MGI:1924233
Macaca mulatta SCFD1 VGNC VGNC:77065
Canis familiaris SCFD1 VGNC VGNC:45903
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