1. Gene
  2. DOCK9 - dedicator of cytokinesis 9 Gene

DOCK9 - dedicator of cytokinesis 9 Gene

中文名称:细胞分裂因子 9

种属: Homo sapiens

同用名: ZIZ1; ZIZIMIN1

基因 ID: 23348 | 基因类型: protein coding

关于 DOCK9

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:98,793,429-99,088,619 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 21.7), thyroid (RPKM 20.1) and 23 other tissues.

功能概要

启用钙粘蛋白结合活动。预计参与 GTPase 活性的正向调节。位于膜内。 [由基因组资源联盟提供,2022 年 4 月]

Enables cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

DOCK9 基因产物(14)

mRNA Protein Name
NM_001130048.2 NP_001123520.1 dedicator of cytokinesis protein 9 isoform b
NM_001130049.2 NP_001123521.1 dedicator of cytokinesis protein 9 isoform c
NM_001130050.2 NP_001123522.1 dedicator of cytokinesis protein 9 isoform d
NM_001318849.2 NP_001305778.1 dedicator of cytokinesis protein 9 isoform e
NM_001366676.2 NP_001353605.1 dedicator of cytokinesis protein 9 isoform 6
NM_001366677.2 NP_001353606.1 dedicator of cytokinesis protein 9 isoform 7
NM_001366678.2 NP_001353607.1 dedicator of cytokinesis protein 9 isoform 8
NM_001366679.2 NP_001353608.1 dedicator of cytokinesis protein 9 isoform 9
NM_001366680.2 NP_001353609.1 dedicator of cytokinesis protein 9 isoform 10
NM_001366681.2 NP_001353610.1 dedicator of cytokinesis protein 9 isoform 11
NM_001366682.2 NP_001353611.1 dedicator of cytokinesis protein 9 isoform 12
NM_001366683.2 NP_001353612.1 dedicator of cytokinesis protein 9 isoform 13
NM_001366684.2 NP_001353613.1 dedicator of cytokinesis protein 9 isoform 14
NM_015296.3 NP_056111.1 dedicator of cytokinesis protein 9 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18729074 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DOCK9 蛋白结构

DUF3398

DUF3398: Domain of unknown function (DUF3398) (59 - 153)

PH

PH: PH domain (175 - 278)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (634 - 827)

DHR-2

DHR-2: Dock homology region 2 (1884 - 2060)

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  • 1600
  • 2068 a.a.
蛋白主名 其他名称

dedicator of cytokinesis protein 9

cdc42 guanine nucleotide exchange factor zizimin-1

DOCK9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DOCK9 Q9BZ29 SMAD3 Homo sapiens P84022
TAP
18729074
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Irregular Astigmatism
Corneal Ectasia
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea

Gapo Syndrome

GAPOS

Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy

Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome

Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2

Brittle Cornea Syndrome 1

Brittle Cornea Syndrome

Fragilitas Oculi With Joint Hyperextensibility

Dysgenesis Mesodermalis Corneae Et Sclerae

BCS1

Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

Ehlers-Danlos Syndrome, Type Vib, Formerly

Eds6b, Formerly

Type Vib Ehlers-Danlos Syndrome

Eds Vib

Ehlers-Danlos Syndrome Type 6b

Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

Eds6b Formerly

Ehlers-Danlos Syndrome Type Vib Formerly

Ehlers-Danlos Syndrome Type 6

Cornea, Brittle, Syndrome

Cornea, Brittle, Syndrome, Type 1

Ehlers-Danlos Syndrome 6b

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DOCK9 VGNC VGNC:61578
Rattus norvegicus DOCK9 RGD RGD:629617
Canis familiaris DOCK9 VGNC VGNC:40053
Bos taurus DOCK9 VGNC VGNC:28163
Mus musculus DOCK9 MGD MGI:106321
Macaca mulatta DOCK9 VGNC VGNC:71835