2. Gene
  3. CRTC1 - CREB regulated transcription coactivator 1 Gene

CRTC1 - CREB regulated transcription coactivator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CREB 调节转录辅激活因子 1

种属: Homo sapiens

同用名: MAML2; MECT1; Mam-2; TORC1; TORC-1; WAMTP1

基因 ID: 23373 | 基因类型: protein coding

关于 CRTC1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,683,680-18,782,333 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in brain (RPKM 4.7), testis (RPKM 2.0) and 24 other tissues.

功能概要

启用 cAMP 反应元件结合蛋白结合活性。参与 RNA 聚合酶 II 对转录的正调控。位于胞质溶胶中；核体；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CRTC1 基因产物(2)

mRNA Protein Name
NM_001098482.2 NP_001091952.1 CREB-regulated transcription coactivator 1 isoform 3
NM_015321.3 NP_056136.2 CREB-regulated transcription coactivator 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP response element binding protein binding IDA
IDA: 通过直接分析推断
14536081 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14506290 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14536081 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
14506290 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRTC1 蛋白结构

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (6 - 66)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (148 - 294)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (559 - 634)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 634 a.a.
蛋白主名 其他名称

CREB-regulated transcription coactivator 1

Mastermind-like protein 2

CRTC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CRTC1 Q6UUV9 YWHAE Homo sapiens P62258
Crosslink
36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mucoepidermoid Carcinoma

Mec

Salivary Gland Mucoepidermoid Carcinoma

C3772

Carcinoma Mucoepidermoid

Carcinoma, Mucoepidermoid
Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms
Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1
Lacrimal Gland Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Lacrimal Gland
Cutaneous Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Skin

Mucoepidermoid Skin Carcinoma
Bronchus Mucoepidermoid Carcinoma
Clear Cell Hidradenoma

Clear Cell Myoepithelioma

Eccrine Acrospiroma
Breast Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Breast

Mucoepidermoid Carcinoma Of The Breast
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos
Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma
Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri
Lipoadenoma
Hidradenoma

Adenoma, Sweat Gland

Hidradenoma Of Skin

Sweat Gland Adenoma

Syringoadenoma

Eccrine Acrospiroma

Benign Neoplasm Of Sweat Gland
Necrotizing Sialometaplasia

Sialometaplasia, Necrotizing
Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma

Adenomyo-Epithelioma

Clear Cell Carcinoma

Emc

Epithelial Myoepithelial Carcinoma

Glycogen-Rich Adenocarcinoma

Glycogen-Rich Adenoma

Monomorphic Clear Cell Tumor

Tubular Solid Adenoma

Adenocarcinoma, Clear Cell
Mammary Analogue Secretory Carcinoma
Endobronchial Lipoma
Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil
Schneiderian Carcinoma

Cylindrical Cell Carcinoma
Bile Duct Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Bile Duct

Extrahepatic Bile Duct Mucoepidermoid Carcinoma
Breast Metaplastic Carcinoma

Metaplastic Carcinoma Of The Breast

Metaplastic Breast Carcinoma

Metaplastic Carcinoma Of Breast

Metaplastic Breast Cancer
Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland

Sweat Gland Tumor

Tumor Of The Sweat Gland

Sweat Gland Neoplasms

Sweat Gland Neoplasm
Esophageal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma, Esophagus
Eccrine Acrospiroma

Acrospiroma

Poroma

Eccrine Hidradenoma

Eccrine Hidradenoma Of Skin

Hidradenoma

Adenoma, Sweat Gland

Benign Neoplasm Of Sweat Gland

Eccrine Poroma
Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma
Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx
Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm

Eccrine Tumor

Eccrine Neoplasm

Malignant Eccrine Neoplasm
Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas
Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma
Acinar Cell Carcinoma

Acinic Cell Carcinoma

Acinic Cell Tumor

Carcinoma Acinar Cell

Carcinoma, Acinar Cell

Acinar Cell Tumor
Lacrimal System Cancer

Neoplasm Of Lacrimal System

Lacrimal System Neoplasm

Tumor Of The Lacrimal System
Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary
Sweat Gland Disease

Sweat Gland Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03200 CRTC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CRTC1 VGNC VGNC:103667
Rattus norvegicus CRTC1 RGD RGD:1589158
Macaca mulatta CRTC1 VGNC VGNC:71418
Mus musculus CRTC1 MGD MGI:2142523
Felis catus CRTC1 VGNC VGNC:61192
Bos taurus CRTC1 VGNC VGNC:27728
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