2. Gene
  3. SMG5 - SMG5 nonsense mediated mRNA decay factor Gene

SMG5 - SMG5 nonsense mediated mRNA decay factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SMG5 无义介导的 mRNA 衰减因子

种属: Homo sapiens

同用名: EST1B; SMG-5; LPTSRP1; LPTS-RP1

基因 ID: 23381 | 基因类型: protein coding

关于 SMG5

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,249,224-156,291,516 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.7), testis (RPKM 16.4) and 25 other tissues.

功能概要

SMG5 参与无义介导的 mRNA 衰变 (Ohnishi 等人，2003 [PubMed 14636577]) 。[OMIM 提供，2008 年 3 月]

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

SMG5 基因产物(5)

mRNA Protein Name
NM_001323614.2 NP_001310543.1 nonsense-mediated mRNA decay factor SMG5 isoform 2
NM_001323615.2 NP_001310544.1 nonsense-mediated mRNA decay factor SMG5 isoform 3
NM_001323616.2 NP_001310545.1 nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_001323617.2 NP_001310546.1 nonsense-mediated mRNA decay factor SMG5 isoform 4
NM_015327.3 NP_056142.2 nonsense-mediated mRNA decay factor SMG5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16809764 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12699629 GOA
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
14636577 GOA
enables telomerase RNA binding IPI
IPI: 通过物理相互作用推断
15857955 GOA
enables telomeric DNA binding IDA
IDA: 通过直接分析推断
17916692 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16809764 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of dephosphorylation IMP
IMP: 通过突变表型推断
14636577 GOA
involved in regulation of telomere maintenance IMP
IMP: 通过突变表型推断
16809764 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14636577 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14636577 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMG5 蛋白结构

EST1

EST1: Telomerase activating protein Est1 (75 - 189)

EST1_DNA_bind

EST1_DNA_bind: Est1 DNA/RNA binding domain (197 - 414)

EST1_DNA_bind

EST1_DNA_bind: Est1 DNA/RNA binding domain (647 - 744)

PIN_4

PIN_4: PIN domain (857 - 941)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1016 a.a.
蛋白主名 其他名称

nonsense-mediated mRNA decay factor SMG5

EST1 telomerase component homolog B

SMG5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SMG5 Q9UPR3 SMG7 Homo sapiens Q92540
Pull Down
23348841
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas
Metaphyseal Chondrodysplasia, Schmid Type

MCDS

Schmid Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia Schmid Type

Spondylometaphyseal Dysplasia, Japanese Type

Japanese Type Spondylometaphyseal Dysplasia

Schmid Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia Type Schmid

Schmid Type Metaphyseal Chondrodysplasia

SMCD

Chondrodysplasia, Metaphyseal, Schmid Type

Corneal Dystrophy, Subepithelial Mucinous
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13431 SMG5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SMG5 VGNC VGNC:65487
Macaca mulatta SMG5 VGNC VGNC:77768
Mus musculus SMG5 MGD MGI:2447364
Bos taurus SMG5 VGNC VGNC:55683
Canis familiaris SMG5 VGNC VGNC:46555
Rattus norvegicus SMG5 RGD RGD:1584731
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