2. Gene
  3. Fus - fused in sarcoma Gene

Fus - fused in sarcoma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Tls; Fus1; D430004D17Rik; D930039C12Rik

基因 ID: 233908 | 基因类型: protein coding

关于 Fus

功能概要

Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Fus 基因产物(2)

mRNA Protein Name
NM_001347649.1 NP_001334578.1 RNA-binding protein FUS isoform 2
NM_139149.2 NP_631888.1 RNA-binding protein FUS isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
27378374 MGI
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
27378374 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23681068 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within RNA splicing IMP
IMP: 通过突变表型推断
27378374 MGI
acts upstream of or within gene expression IGI
IGI: 通过遗传相互作用推断
27378374 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
27378374 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
34021139 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12950080 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
34021139 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12950080 MGI
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
34021139 MGI
is active in presynaptic cytosol IDA
IDA: 通过直接分析推断
34021139 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

RNA-binding protein FUS

fusion, derived from t(12

16) malignant liposarcoma

hnRNP P2

pigpen protein

protein pigpen

translocated in liposarcoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-147410 Ulefnersen / Phase 3
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147410A Ulefnersen sodium 94.55% 否
HY-RS05149 FUS Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fus NCBI NCBI:2521
Canis familiaris Fus NCBI NCBI:100856381
Macaca fascicularis Fus NCBI NCBI:101925561
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