FOLR2 - folate receptor beta Gene

中文名称：叶酸受体β

种属: Homo sapiens

同用名: FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1

基因 ID: 2350 | 基因类型: protein coding

关于 FOLR2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,216,794-72,221,950 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues.

功能概要

该基因编码的蛋白质是叶酸受体 (FOLR) 家族的成员，这些基因成簇存在于 11 号染色体上。该基因家族的成员对叶酸和几种还原叶酸衍生物具有高亲和力，并且它们介导 5-甲基四氢叶酸向细胞内部的递送。该蛋白与 FOLR1 和 FOLR3 蛋白的序列同源性分别为 68% 和 79%。虽然这种蛋白质最初被认为是胎盘特有的，但它也可以存在于其他组织中，它可能在类风湿关节炎患者的滑膜巨噬细胞中对甲氨蝶呤的转运发挥作用。已发现该基因编码相同蛋白质的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in Other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

FOLR2 基因产物(4)

mRNA	Protein	Name
NM_000803.5	NP_000794.3	folate receptor beta precursor
NM_001113534.2	NP_001107006.1	folate receptor beta precursor
NM_001113535.2	NP_001107007.1	folate receptor beta precursor
NM_001113536.2	NP_001107008.1	folate receptor beta precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables folic acid binding	IDA IDA: 通过直接分析推断	4066659	GOA
enables folic acid receptor activity	IDA IDA: 通过直接分析推断	4066659	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in folic acid transport	IDA IDA: 通过直接分析推断	4066659	GOA
NOT involved in monocyte chemotaxis	IDA IDA: 通过直接分析推断	25015955	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	19116913	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	25015955	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	4066659	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOLR2 蛋白结构

Folate_rec

0
100
200
255 a.a.

蛋白主名

其他名称

folate receptor beta

folate receptor 2 (fetal)

重组 FOLR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76348	FOLR2 Protein, Human (HEK293, His)	P14207 (T17-H228)	≥95%

关联疾病

疾病名称

别名

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Choriocarcinoma Of The Testis

Testicular Choriocarcinoma

Myelomeningocele

Meningomyelocele

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Subacute Leukemia

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05030	FOLR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FOLR2	VGNC	VGNC:72690
Rattus norvegicus	FOLR2	RGD	RGD:1308515
Mus musculus	FOLR2	MGD	MGI:95569
Macaca fascicularis	FOLR2	NCBI
Others	FOLR2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FOLR2 - folate receptor beta Gene

关于 FOLR2

功能概要

FOLR2 基因产物(4)

FOLR2 蛋白结构

重组 FOLR2 蛋白

关联疾病

直系同源

热门区域

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FOLR2 - folate receptor beta Gene

关于 FOLR2

功能概要

FOLR2 基因产物(4)

FOLR2 蛋白结构

重组 FOLR2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z