MORC3 - MORC family CW-type zinc finger 3 Gene

中文名称：MORC 家族 CW 型锌指 3

种属: Homo sapiens

同用名: NXP2; ZCW5; ZCWCC3

基因 ID: 23515 | 基因类型: protein coding

关于 MORC3

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,320,197-36,376,632 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues.

功能概要

该基因编码一种定位于核基质并通过 ATP 依赖机制形成核体的蛋白质。预计该蛋白质具有卷曲螺旋和锌指结构域，并具有 RNA 结合活性。可变剪接产生编码不同亚型的多个转录变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

MORC3 基因产物(3)

mRNA	Protein	Name
NM_001320445.2	NP_001307374.1	MORC family CW-type zinc finger protein 3 isoform 2
NM_001320446.2	NP_001307375.1	MORC family CW-type zinc finger protein 3 isoform 2
NM_015358.3	NP_056173.1	MORC family CW-type zinc finger protein 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	34759314	GOA
enables methylated histone binding	IDA IDA: 通过直接分析推断	26933034	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	26496610	GOA
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	27440897	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	27440897	GOA
acts upstream of or within maintenance of protein location in nucleus	IDA IDA: 通过直接分析推断	17332504	GOA
acts upstream of or within maintenance of protein location in nucleus	IMP IMP: 通过突变表型推断	17332504	GOA
acts upstream of or within negative regulation of fibroblast proliferation	IDA IDA: 通过直接分析推断	17332504	GOA
involved in negative regulation of interferon-beta production	IDA IDA: 通过直接分析推断	34759314	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	34759314	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	17332504	GOA
acts upstream of or within positive regulation of cellular senescence	IDA IDA: 通过直接分析推断	17332504	GOA
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	17332504	GOA
acts upstream of or within protein stabilization	IDA IDA: 通过直接分析推断	17332504	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in PML body	IDA IDA: 通过直接分析推断	27440897	GOA
located in PML body	IDA IDA: 通过直接分析推断	17332504	GOA
located in chromatin	IDA IDA: 通过直接分析推断	34759314	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MORC3 蛋白结构

HATPase_c_3

zf-CW

0
200
400
600
800
939 a.a.

蛋白主名

其他名称

MORC family CW-type zinc finger protein 3

nuclear matrix protein 2

MORC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MORC3	Q14149	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	26496610
种属内	MORC3	Q14149	DYNLL1	Homo sapiens	P63167	Y2H Fragment Pooling	35914814
种属内	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
种属内	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
种属内	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MORC3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71545	MORC3 Protein, Human (His-SUMO)	Q14149 (1M-290Y)	≥95%

关联疾病

疾病名称

别名

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Orbital Plasma Cell Granuloma

Orbital Myositis	Orbital Pseudotumor
Pseudotumor Of Orbit	Plasma Cell Granuloma, Orbital

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Renal Pelvis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Kidney Pelvis

Squamous Cell Carcinoma Of Renal Pelvis

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Chronic Orbital Inflammation

Chronic Inflammation Of Orbit

Nodular Prostate

Muscle Tissue Disease

Exanthem

Exanthema	Rash
Rashes

Muscular Disease

Myopathy

Muscular Diseases

Myopathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08591	MORC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MORC3	VGNC	VGNC:74809
Rattus norvegicus	MORC3	RGD	RGD:1307924
Bos taurus	MORC3	VGNC	VGNC:31556
Mus musculus	MORC3	MGD	MGI:2136841
Canis familiaris	MORC3	VGNC	VGNC:43318
Felis catus	MORC3	VGNC	VGNC:63558
Others	MORC3	NCBI

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