2. Gene
  3. FOLR3 - folate receptor gamma Gene

FOLR3 - folate receptor gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叶酸受体γ

种属: Homo sapiens

同用名: FR-G; FRgamma; FR-gamma; gamma-hFR

基因 ID: 2352 | 基因类型: protein coding

关于 FOLR3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,135,725-72,139,892 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 27.0), appendix (RPKM 4.9) and 3 other tissues.

功能概要

该基因编码叶酸受体 (FOLR) 蛋白家族的成员，该蛋白对叶酸和几种还原叶酸衍生物具有高亲和力，并介导 5-甲基四氢叶酸向细胞内部的递送。该基因的表达可能在卵巢癌和原发性腹膜癌中升高。该基因存在于 11 号染色体上的基因簇中。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

FOLR3 基因产物(2)

mRNA Protein Name
NM_000804.4 NP_000795.2 folate receptor gamma isoform 1 precursor
NM_001412270.1 NP_001399199.1 folate receptor gamma isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOLR3 蛋白结构

Folate_rec

Folate_rec: Folate receptor family (146 - 253)

  • 0
  • 100
  • 200
  • 287 a.a.
蛋白主名 其他名称

folate receptor gamma

folate receptor 3 (gamma)

FOLR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOLR3 P41439 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
种属内
FOLR3 P41439 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FOLR3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78766 FOLR3 Protein, Human (HEK293, His) P41439 (Q23-S245) ≥95%

关联疾病

疾病名称 别名
Primary Peritoneal Carcinoma

Serous Surface Papillary Carcinoma

Eoppc

Extra-Ovarian Primary Peritoneal Carcinoma

Ppc

Primary Peritoneal Serous Carcinoma

Primary Peritoneal Serous Adenocarcinoma
Choriocarcinoma Of The Testis

Testicular Choriocarcinoma
Subacute Leukemia
Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption

Congenital Defect Of Folate Absorption

Congenital Folate Malabsorption

Folic Acid Transport Defect

HFM
Exudative Vitreoretinopathy 3

EVR3
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05031 FOLR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus FOLR3 MGD MGI:95569
Others FOLR3 NCBI
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