2. Gene
  3. SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1 Gene

SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：单链选择性单功能尿嘧啶 DNA 糖基化酶 1

种属: Homo sapiens

同用名: FDG; UNG3; HMUDG

基因 ID: 23583 | 基因类型: protein coding

关于 SMUG1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,158,235-54,188,985 (from NCBI)

This gene has 26 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in skin (RPKM 3.7), placenta (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质通过从单链和双链 DNA 中去除尿嘧啶参与碱基切除修复。该基因存在许多可变剪接的转录本变体；全长性质以某些但不是所有变体而闻名。[RefSeq 提供，2011 年 8 月]

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

SMUG1 基因产物(32)

mRNA Protein Name
NM_001243787.2 NP_001230716.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243788.2 NP_001230717.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243789.2 NP_001230718.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243790.2 NP_001230719.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243791.2 NP_001230720.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351237.2 NP_001338166.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351238.2 NP_001338167.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351239.2 NP_001338168.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351240.2 NP_001338169.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351241.2 NP_001338170.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351242.2 NP_001338171.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351243.2 NP_001338172.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351244.2 NP_001338173.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351245.2 NP_001338174.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351246.2 NP_001338175.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351247.2 NP_001338176.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351248.2 NP_001338177.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351249.2 NP_001338178.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351250.2 NP_001338179.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351251.2 NP_001338180.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351252.2 NP_001338181.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351253.2 NP_001338182.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351254.2 NP_001338183.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351255.2 NP_001338184.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351256.2 NP_001338185.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351257.2 NP_001338186.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351258.2 NP_001338187.1 single-strand selective monofunctional uracil DNA glycosylase isoform 3
NM_001351259.2 NP_001338188.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351260.2 NP_001338189.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351261.2 NP_001338190.1 single-strand selective monofunctional uracil DNA glycosylase isoform 5
NM_001351262.2 NP_001338191.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_014311.3 NP_055126.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA N-glycosylase activity IDA
IDA: 通过直接分析推断
11526119 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables single-strand selective uracil DNA N-glycosylase activity IDA
IDA: 通过直接分析推断
12161446 GOA
enables uracil DNA N-glycosylase activity IDA
IDA: 通过直接分析推断
12718543 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in base-excision repair IDA
IDA: 通过直接分析推断
12161446 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
12161446 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMUG1 蛋白结构

UDG

UDG: Uracil DNA glycosylase superfamily (71 - 262)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

single-strand selective monofunctional uracil DNA glycosylase

SMUG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SMUG1 Q53HV7 VAC14 Homo sapiens Q08AM6
Y2H Array
29892012
种属内
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Y2H Prey Pooling
26871637
种属内
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Validated Y2H
26871637
种属内
SMUG1 Q53HV7 SKIL Homo sapiens P12757
Y2H Array
26871637
种属内
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Y2H Array
26871637
种属内
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Y2H Prey Pooling
26871637
种属内
SMUG1 Q53HV7 CDC23 Homo sapiens Q9UJX2
Validated Y2H
26871637
种属内
SMUG1 Q53HV7 RBPMS Homo sapiens Q93062
Pull Down
16189514
种属内
SMUG1 Q53HV7 CRX Homo sapiens O43186
Y2H Prey Pooling
26871637
种属内
SMUG1 Q53HV7 CRX Homo sapiens O43186
Validated Y2H
26871637
种属内
SMUG1 Q53HV7 CRX Homo sapiens O43186
Y2H Array
26871637
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SMUG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71560 SMUG1 Protein, Human (His-SUMO) Q53HV7 (1M-177L) ≥95%

关联疾病

疾病名称 别名
Rectosigmoid Junction Neoplasm

Neoplasm Of Rectosigmoid Junction

Rectosigmoid Neoplasm

Rectosigmoid Tumor

Rectosigmoid Carcinoma

Carcinoma Of The Rectosigmoid Junction

Malignant Tumor Of Rectosigmoid Junction

Rectosigmoid Junction Cancer

Primary Malignant Neoplasm Of Rectosigmoid Junction

Rectosigmoid Colon Cancer

Carcinoma Of Rectum With Sigmoid

Colorectal Cancer Nos

Colorectal Carcinoma Nos

Rectosigmoid Cancer
Immunodeficiency With Hyper-Igm, Type 5

HIGM5

Hyper-Igm Syndrome 5

Immunodeficiency With Hyper Igm Type 5

Hyper-Igm Syndrome Type 5

Hyper-Igm Syndrome Due To Ung Deficiency

Hyper-Igm Syndrome Due To Uracil N-Glycosylase

Immunodeficiency With Hyper Igm, Type 5

Hyper Igm Syndrome 5

Immunodeficiency With Hyper-Igm 5

Hyper-Igm Immunodeficiency Type 5

Immunodeficiency, With Hyper Igm, Type 5

Hyper-Igm Immunodeficiency Syndrome, Type 5
Sigmoid Neoplasm

Sigmoid Neoplasms

Neoplasm Of Sigmoid Colon

Tumor Of Sigmoid Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13458 SMUG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SMUG1 VGNC VGNC:65509
Rattus norvegicus SMUG1 RGD RGD:631403
Mus musculus SMUG1 MGD MGI:1918976
Bos taurus SMUG1 VGNC VGNC:35039
Macaca mulatta SMUG1 VGNC VGNC:77730
Canis familiaris SMUG1 VGNC VGNC:46579
Others SMUG1 NCBI
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