1. Gene
  2. OPN3 - opsin 3 Gene

OPN3 - opsin 3 Gene

中文名称:视蛋白 3

种属: Homo sapiens

同用名: ECPN; PPP1R116

基因 ID: 23596 | 基因类型: protein coding

关于 OPN3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,593,124-241,640,369 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 9 paralogues. Broad expression in placenta (RPKM 19.5), lung (RPKM 11.0) and 24 other tissues.

功能概要

视蛋白是鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体超家族的成员。除了视觉视蛋白外,哺乳动物还拥有几种在眼外组织中表达的感光性非视觉视蛋白。这种基因,即视蛋白 3,在大脑和睾丸中表达强烈,在肝脏、胎盘、心脏、肺、骨骼肌、肾脏和胰腺中表达微弱。该基因也可以在视网膜中表达。该蛋白质具有感光视蛋白的典型特征。[RefSeq 提供,2008 年 7 月]

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

OPN3 基因产物(3)

mRNA Protein Name
NM_001381855.1 NP_001368784.1 opsin-3 isoform 2
NM_001381856.1 NP_001368785.1 opsin-3 isoform 3
NM_014322.3 NP_055137.2 opsin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 11-cis retinal binding IDA
IDA: 通过直接分析推断
31097585 GOA
enables all-trans retinal binding IDA
IDA: 通过直接分析推断
31097585 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31097585 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV-A IDA
IDA: 通过直接分析推断
31380578 GOA
involved in keratinocyte differentiation IMP
IMP: 通过突变表型推断
30168605 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
31730232 GOA
involved in negative regulation of melanin biosynthetic process IMP
IMP: 通过突变表型推断
31097585 GOA
involved in positive regulation of melanin biosynthetic process IMP
IMP: 通过突变表型推断
28842328 GOA
involved in response to blue light IDA
IDA: 通过直接分析推断
30168605 GOA
involved in response to blue light IMP
IMP: 通过突变表型推断
28842328 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
30168605 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
30168605 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OPN3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (59 - 309)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

opsin-3

encephalopsin

OPN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726 31097585
种属内
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726 31097585
种属内
OPN3 Q9H1Y3 MC1R Homo sapiens Q01726 31097585
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OPN3 VGNC VGNC:75400
Rattus norvegicus OPN3 RGD RGD:1594385
Felis catus OPN3 VGNC VGNC:107908
Mus musculus OPN3 MGD MGI:1338022
Canis familiaris OPN3 VGNC VGNC:44130