CLEC5A - C-type lectin domain containing 5A Gene

中文名称：含 C 型凝集素结构域 5A

种属: Homo sapiens

同用名: MDL1; MDL-1; CLECSF5

基因 ID: 23601 | 基因类型: protein coding

关于 CLEC5A

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:141,927,357-141,946,974 (from NCBI)

This gene has 7 transcripts (splice variants), 224 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 12.6), appendix (RPKM 4.1) and 6 other tissues.

功能概要

该基因编码 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。该家族的成员具有共同的蛋白质折叠并具有多种功能，例如细胞粘附、细胞间信号传导、糖蛋白转换以及在炎症和免疫反应中的作用。编码的 II 型跨膜蛋白与 dnax 激活蛋白 12 相互作用，可能在细胞激活中发挥作用。已经描述了替代剪接变体，但尚未确定它们的全长序列。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

CLEC5A 基因产物(2)

mRNA	Protein	Name
NM_001301167.2	NP_001288096.1	C-type lectin domain family 5 member A isoform 2
NM_013252.3	NP_037384.1	C-type lectin domain family 5 member A isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables virus receptor activity	IDA IDA: 通过直接分析推断	18496526	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in innate immune response	IDA IDA: 通过直接分析推断	18496526	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLEC5A 蛋白结构

Lectin_C

0
100
188 a.a.

蛋白主名

其他名称

C-type lectin domain family 5 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5

重组 CLEC5A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77632	CLEC5A/MDL-1 Protein, Human (HEK293, Fc)	Q9NY25 (Y26-K188)	≥95%

关联疾病

疾病名称

别名

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

Dengue Shock Syndrome

Dss

Dengue Disease

Dengue Fever	Dengue
Df	Dengue Shock Syndrome
Dengue Virus Infection	Breakbone Fever
Classic Dengue	Classical Dengue
Dengue Hemorrhagic Fever	Hemorrhagic Dengue
Philippine Hemorrhagic Fever	Singapore Hemorrhagic Fever
Thai Hemorrhagic Fever	Severe Dengue
Dengue Fever Without Warning Signs	Dengue Haemorrhagic Fever Grade 1
Dengue Haemorrhagic Fever Without Warning Signs	Bangkok Haemorrhagic Fever
Singapore Haemorrhagic Fever	Thailand Haemorrhagic Fever
Southeast Asia Haemorrhagic Fever	Dhf -[Dengue Haemorrhagic Fever]
Dengue Fever With Warning Signs	Dengue Haemorrhagic Fever With Warning Signs
Dengue Haemorrhagic Fever Grade 2	Philippine Haemorrhagic Fever

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02798	CLEC5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CLEC5A	VGNC	VGNC:39334
Felis catus	CLEC5A	VGNC	VGNC:60954
Mus musculus	CLEC5A	MGD	MGI:1345151
Rattus norvegicus	CLEC5A	RGD	RGD:1584755
Bos taurus	CLEC5A	VGNC	VGNC:27435
Macaca mulatta	CLEC5A	VGNC	VGNC:71252
Others	CLEC5A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLEC5A - C-type lectin domain containing 5A Gene

关于 CLEC5A

功能概要

CLEC5A 基因产物(2)

CLEC5A 蛋白结构

重组 CLEC5A 蛋白

关联疾病

直系同源

热门区域

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CLEC5A - C-type lectin domain containing 5A Gene

关于 CLEC5A

功能概要

CLEC5A 基因产物(2)

CLEC5A 蛋白结构

重组 CLEC5A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z