1. Gene
  2. CBLC - Cbl proto-oncogene C Gene

CBLC - Cbl proto-oncogene C Gene

中文名称:Cbl 原癌基因 C

种属: Homo sapiens

同用名: CBL-3; RNF57; CBL-SL

基因 ID: 23624 | 基因类型: protein coding

关于 CBLC

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,777,869-44,800,652 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues, 2 paralogues and is associated with 60 phenotypes. Biased expression in duodenum (RPKM 19.1), small intestine (RPKM 14.9) and 11 other tissues.

功能概要

该基因编码 E3 泛素连接酶的 Cbl 家族成员。 Cbl 蛋白通过泛素化和随后的酪氨酸激酶下调在细胞信号传导中发挥重要作用。该基因的表达可能仅限于上皮细胞,并且已经观察到该基因编码多种同种型的选择性剪接转录物变体。[RefSeq 提供,2012 年 2 月]

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CBLC 基因产物(2)

mRNA Protein Name
NM_001130852.1 NP_001124324.1 E3 ubiquitin-protein ligase CBL-C isoform 2
NM_012116.4 NP_036248.3 E3 ubiquitin-protein ligase CBL-C isoform 1

CBLC 蛋白结构

Cbl_N

Cbl_N: CBL proto-oncogene N-terminal domain 1 (14 - 145)

Cbl_N2

Cbl_N2: CBL proto-oncogene N-terminus, EF hand-like domain (148 - 232)

Cbl_N3

Cbl_N3: CBL proto-oncogene N-terminus, SH2-like domain (234 - 319)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (350 - 394)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase CBL-C

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

CBLC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CBLC Q9ULV8 UBE2K Homo sapiens P61086 32814053
种属内
CBLC Q9ULV8 UBE2K Homo sapiens P61086 32814053
种属内
CBLC Q9ULV8 UBE2K Homo sapiens P61086 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CBLC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74343 CBLC Protein, Human (sf9, His-GST) AAH28915.1 (M1-A474) ≥95%

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CBLC VGNC VGNC:108489
Felis catus CBLC VGNC VGNC:60422
Rattus norvegicus CBLC RGD RGD:1307651
Canis familiaris CBLC VGNC VGNC:38760
Bos taurus CBLC VGNC VGNC:26810
Mus musculus CBLC MGD MGI:1931457
Others CBLC NCBI