2. Gene
  3. OSBP2 - oxysterol binding protein 2 Gene

OSBP2 - oxysterol binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：氧固醇结合蛋白 2

种属: Homo sapiens

同用名: HLM; ORP4; ORP-4; OSBPL1; OSBPL4

基因 ID: 23762 | 基因类型: protein coding

关于 OSBP2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,693,782-30,907,813 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 11 paralogues. Broad expression in bone marrow (RPKM 10.4), testis (RPKM 8.8) and 17 other tissues.

功能概要

该基因编码的蛋白质包含一个 pleckstrin 同源 (PH) 结构域和一个氧甾醇结合区。它结合氧固醇，如 7-酮胆固醇，并可能抑制它们的细胞毒性。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

OSBP2 基因产物(6)

mRNA Protein Name
NM_001282738.2 NP_001269667.1 oxysterol-binding protein 2 isoform c
NM_001282739.2 NP_001269668.1 oxysterol-binding protein 2 isoform d
NM_001282740.2 NP_001269669.1 oxysterol-binding protein 2 isoform e
NM_001282741.2 NP_001269670.1 oxysterol-binding protein 2 isoform f
NM_001282742.2 NP_001269671.1 oxysterol-binding protein 2 isoform g
NM_030758.4 NP_110385.1 oxysterol-binding protein 2 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholesterol binding IDA
IDA: 通过直接分析推断
17428193 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OSBP2 蛋白结构

PH

PH: PH domain (186 - 271)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (522 - 902)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 916 a.a.
蛋白主名 其他名称

oxysterol-binding protein 2

OSBP-related protein 4

OSBP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OSBP2 Q969R2 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
种属内
OSBP2 Q969R2 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Opisthorchiasis

Infection By Opisthorchis

Infection Due To Opisthorchis

Infection Due To Cat Liver Fluke

Infection By Cat Liver Fluke

Opisthorchiosis

Cat Liver Fluke Fever

Cat Liver Fluke Disease

Opisthorchis Infestation

Cat Liver Fluke Infestation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09836 OSBP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus OSBP2 MGD MGI:1921559
Macaca mulatta OSBP2 VGNC VGNC:75719
Rattus norvegicus OSBP2 RGD RGD:1310505
Bos taurus OSBP2 VGNC VGNC:32457
Felis catus OSBP2 VGNC VGNC:68657
Canis familiaris OSBP2 VGNC VGNC:44150
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