1. Gene
  2. Aplnr - apelin receptor Gene

Aplnr - apelin receptor Gene

中文名称:apelin受体

种属: Mus musculus

同用名: APJ; Agtrl1; msr/apj

基因 ID: 23796 | 基因类型: protein coding

关于 Aplnr

Chromosome 2: 84,966,569-84,970,267 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 172 orthologues, 9 paralogues and is associated with 26 phenotypes.

功能概要

预测该基因编码的蛋白可启动apelin受体活性。参与多个过程,包括apelin受体信号通路;循环系统发育;和血管内皮细胞增殖的正调节参与新血管生成。在缝隙连接组件的调节上游或调节内起作用。预测位于膜中。预计在质膜上有活性。以多种结构表达,包括消化系统;心血管系统;中枢神经系统;胚胎间充质;和生殖系统。与人类 APLNR(apelin 受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable apelin receptor activity. Involved in several processes, including apelin receptor signaling pathway; circulatory system development; and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Acts upstream of or within regulation of gap junction assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and reproductive system. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Aplnr 基因产物(1)

mRNA Protein Name
NM_011784.3 NP_035914.1 apelin receptor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adult heart development IMP
IMP: 通过突变表型推断
28663440 MGI
involved in aorta development IMP
IMP: 通过突变表型推断
23603510 MGI
involved in atrioventricular valve development IMP
IMP: 通过突变表型推断
23603510 MGI
involved in coronary vasculature development IMP
IMP: 通过突变表型推断
23603510 MGI
involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
23603510 MGI
involved in heart looping IMP
IMP: 通过突变表型推断
23603510 MGI
acts upstream of negative regulation of gene expression IMP
IMP: 通过突变表型推断
23603510 MGI
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
28890073 MGI
acts upstream of or within regulation of gap junction assembly IMP
IMP: 通过突变表型推断
23603510 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
23603510 MGI
involved in vascular associated smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
23603510 MGI
involved in vasculature development IMP
IMP: 通过突变表型推断
23603510 MGI
involved in vasculogenesis IMP
IMP: 通过突变表型推断
28663440 MGI
involved in venous blood vessel development IMP
IMP: 通过突变表型推断
23603510 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
23603510 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Aplnr 蛋白结构

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (16 - 317)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (27 - 53)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (61 - 86)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (99 - 129)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (142 - 163)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (195 - 224)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (238 - 268)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
蛋白主名 其他名称

apelin receptor

G-protein coupled receptor APJ

MSR

angiotensin receptor-like 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aplnr NCBI NCBI:187