1. Gene
  2. Pik3c2b - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

Pik3c2b - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

中文名称:磷脂酰肌醇 4-磷酸 3-激酶催化亚基 2 型

种属: Mus musculus

同用名: Gm199; PI3KC2beta; PI3K-C2beta; C330011J12Rik

基因 ID: 240752 | 基因类型: protein coding

关于 Pik3c2b

Chromosome 1: 132,973,405-133,036,425 forward strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in colon adult (RPKM 14.), spleen adult (RPKM 1.9) and 24 other tissues.

功能概要

该基因编码的蛋白可启动脂质激酶活性。作用于多个过程的上游或内部,包括自噬体组织;磷脂酰肌醇-3-磷酸生物合成过程;和蛋白激酶 B 信号。位于内吞囊泡中。用眼睛表达;肢;神经系统;和骨架。与人 PIK3C2B(磷脂酰肌醇 4 磷酸 3 激酶催化亚基 2 型 beta)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables lipid kinase activity. Acts upstream of or within several processes, including autophagosome organization; phosphatidylinositol-3-phosphate biosynthetic process; and protein kinase B signaling. Located in endocytic vesicle. Is expressed in eye; limb; nervous system; and skeleton. Orthologous to human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2b 基因产物(1)

mRNA Protein Name
NM_001099276.2 NP_001092746.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipid kinase activity IDA
IDA: 通过直接分析推断
17875942 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17875942 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within autophagosome organization IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within cellular response to starvation IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within macroautophagy IGI
IGI: 通过遗传相互作用推断
24098492 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
17875942 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IGI
IGI: 通过遗传相互作用推断
24098492 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endocytic vesicle IDA
IDA: 通过直接分析推断
17875942 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Pik3c2b 蛋白结构

PI3K_rbd

PI3K_rbd: pfam00794 (362 - 464)

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (620 - 792)

PI3Ka_II

PI3Ka_II: cd00869 (811 - 979)

PI3Kc_C2_beta

PI3Kc_C2_beta: cd00895 (985 - 1338)

PX_PI3K_C2_beta

PX_PI3K_C2_beta: cd07290 (1367 - 1475)

C2B_PI3K_class_II

C2B_PI3K_class_II: cd08381 (1503 - 1625)

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  • 1632 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

phosphoinositide-3-kinase, class 2, beta polypeptide

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pik3c2b NCBI NCBI:5287