PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Gene

中文名称：磷脂酰肌醇 4-磷酸 3-激酶催化亚基 2 型

种属: Homo sapiens

同用名: C2-PI3K

关于 PIK3C2B

功能概要

该基因编码的蛋白质属于磷酸肌醇 3-激酶 (PI3K) 家族。 PI3-激酶在涉及细胞增殖、致癌转化、细胞存活、细胞迁移和细胞内蛋白质运输的信号通路中发挥作用。该蛋白质包含脂质激酶催化结构域以及 C 末端 C2 结构域，这是 II 类 PI3 激酶的特征。 C2 结构域充当钙依赖性磷脂结合基序，介导蛋白质向膜的易位，并且还可以介导蛋白质-蛋白质相互作用。这种蛋白质的 PI3 激酶活性对低纳摩尔水平的抑制剂 wortmanin 很敏感。该蛋白的 C2 结构域显示可结合磷脂但不结合 Ca2+，这表明该酶可能以钙非依赖性方式发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind Phospholipids but not Ca2+, which suggests that this Enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]