2. Gene
  3. Tnfsf18 - tumor necrosis factor (ligand) superfamily, member 18 Gene

Tnfsf18 - tumor necrosis factor (ligand) superfamily, member 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gitrl; Tnlg2a

基因 ID: 240873 | 基因类型: protein coding

关于 Tnfsf18

功能概要

Enables identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Located in cell surface. Is expressed in skin; submandibular gland; and thyroid gland. Orthologous to human TNFSF18 (TNF Superfamily member 18). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf18 基因产物(1)

mRNA Protein Name
NM_183391.4 NP_899247.3 tumor necrosis factor ligand superfamily member 18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18178614 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14647196 MGI
enables tumor necrosis factor receptor superfamily binding IDA
IDA: 通过直接分析推断
14521928 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell proliferation involved in immune response IDA
IDA: 通过直接分析推断
14608036 MGI
NOT involved in activated CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
24107315 MGI
involved in negative regulation of T-helper 17 cell lineage commitment IMP
IMP: 通过突变表型推断
24107315 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
14521928 MGI
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
23892569 MGI
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
24107315 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
24107315 MGI
involved in positive regulation of monocyte chemotaxis IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in regulation of CD40 signaling pathway IMP
IMP: 通过突变表型推断
24107315 MGI
involved in regulation of T cell proliferation IDA
IDA: 通过直接分析推断
14608036 MGI
involved in regulation of dendritic cell chemotaxis IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in regulation of monocyte chemotactic protein-1 production IMP
IMP: 通过突变表型推断
24107315 MGI
involved in regulation of protein-containing complex assembly IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
24107315 MGI
NOT involved in regulation of type II interferon production IMP
IMP: 通过突变表型推断
24107315 MGI
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
14521928 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
14521928 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 18

GITR ligand

glucocorticoid-induced TNF-related ligand

glucocorticoid-induced-tumor necrosis factor receptor ligand

tumor necrosis factor ligand 2a

Tnfsf18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tnfsf18 Q7TS55 Tnfsf18 Mus musculus Q7TS55
X-Ray Diffraction
18178614
种属内
Tnfsf18 Q7TS55 Tnfrsf18 Mus musculus O35714
Pull Down
14647196
种属内
Tnfsf18 Q7TS55 Tnfrsf18 Mus musculus O35714
SPR
18182486
种属内
Tnfsf18 Q7TS55 Tnfsf18 Mus musculus Q7TS55
Solution Sedimentation
18178614
种属内
Tnfsf18 Q7TS55 Tnfsf18 Mus musculus Q7TS55
GMS
18182486
种属内
Tnfsf18 Q7TS55 Tnfsf18 Mus musculus Q7TS55
X-Ray Diffraction
18182486
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Tnfsf18 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7319 AITRL/TNFSF18 Protein, Mouse Q7TS55 (T47-S173) ≥95%
HY-P78299 AITRL/TNFSF18 Protein, Mouse (HEK293, Fc) Q7TS55 (T47-S173) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14827 TNFSF18 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfsf18 NCBI NCBI:8995
Macaca fascicularis Tnfsf18 NCBI NCBI:102140808
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