EDNRA - endothelin receptor type A Gene

中文名称：内皮素受体A型

种属: Rattus norvegicus

同用名: Eta; ET-A; ET-AR; Endor; RGD1559432

关于 EDNRA

功能概要

该基因编码的蛋白可启动内皮素受体活性。涉及多个过程，包括细胞对机械刺激的反应；肾小球滤过；和细胞溶质钙离子浓度的正调节。位于T管和核膜。与膜筏共定位。用于研究高血压；心肌梗塞;门静脉高压症;肺气肿;和肺动脉高压。多种疾病的生物标志物，包括高同型半胱氨酸血症；阳痿;阻塞性睡眠呼吸暂停;肾纤维化；和 2 型糖尿病。与高血压有关的该基因的人类直系同源物（多个）；肺部疾病;伴有脱发的颌面骨发育不全；偏头痛;和阻塞性睡眠呼吸暂停。与人 EDNRA（A 型内皮素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Endothelin Receptor activity. Involved in several processes, including cellular response to mechanical stimulus; glomerular filtration; and positive regulation of cytosolic calcium ion concentration. Located in T-tubule and nuclear membrane. Colocalizes with membrane raft. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (Endothelin Receptor type A). [provided by Alliance of Genome Resources, Apr 2022]