2. Gene
  3. Grm6 - glutamate metabotropic receptor 6 Gene

Grm6 - glutamate metabotropic receptor 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢型受体 6

种属: Rattus norvegicus

同用名: mGluR6

基因 ID: 24419 | 基因类型: protein coding

关于 Grm6

Primary_assembly 10: 35,167,985-35,182,717 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 250 orthologues, 7 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 2.1), Testes (RPKM .8) and 6 other tissues.

功能概要

使腺苷酸环化酶抑制 G 蛋白偶联谷氨酸受体活性。参与腺苷酸环化酶抑制 G 蛋白偶联谷氨酸受体信号通路和化学突触传递。预测位于高尔基体膜；内质网膜；和新生长的细胞尖端。预计是质膜的组成部分。该基因的人类直系同源物与先天性静止性夜盲症 1B 相关。与人类 GRM6（谷氨酸代谢受体 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway and chemical synaptic transmission. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and new growing cell tip. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Grm6 基因产物(1)

mRNA Protein Name
NM_022920.2 NP_075209.1 metabotropic glutamate receptor 6 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA
IDA: 通过直接分析推断
8389366 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
8389366 RGD
involved in chemical synaptic transmission IEP
IEP: 通过表达模式推断
8389366 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm6 蛋白结构

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (38 - 499)

NCD3G

NCD3G: pfam07562 (507 - 557)

7tm_GPCRs

7tm_GPCRs: cl28897 (577 - 849)

7tm_GPCRs

7tm_GPCRs: cd14964 (578 - 602)

7tm_GPCRs

7tm_GPCRs: cd14964 (614 - 635)

7tm_GPCRs

7tm_GPCRs: cd14964 (644 - 666)

7tm_GPCRs

7tm_GPCRs: cd14964 (692 - 708)

7tm_GPCRs

7tm_GPCRs: cd14964 (740 - 763)

7tm_GPCRs

7tm_GPCRs: cd14964 (775 - 797)

7tm_GPCRs

7tm_GPCRs: cd14964 (807 - 832)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 871 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 6

glutamate receptor, metabotropic 6

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05834 GRM6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05835 Grm6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05836 Grm6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm6 NCBI NCBI:2916
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