1. Gene
  2. Hrh1 - histamine receptor H 1 Gene

Hrh1 - histamine receptor H 1 Gene

中文名称:组胺受体H 1

种属: Rattus norvegicus

同用名: Hisr

基因 ID: 24448 | 基因类型: protein coding

关于 Hrh1

Primary_assembly 4: 147,645,995-147,647,455 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 186 orthologues, 35 paralogues and is associated with 12 phenotypes.

功能概要

该基因编码的蛋白可启动组胺结合活动。参与多个过程,包括类固醇生物合成过程的负调控;一氧化氮生物合成过程的正调控;和血管收缩的正调节作用。预测位于胞质溶胶和质膜中。预计在树突中活跃。预计是质膜的组成部分。与人类 HRH1(组胺受体 H1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables histamine binding activity. Involved in several processes, including negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; and positive regulation of vasoconstriction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Orthologous to human HRH1 (Histamine Receptor H1). [provided by Alliance of Genome Resources, Apr 2022]

Hrh1 基因产物(1)

mRNA Protein Name
NM_017018.2 NP_058714.2 histamine H1 receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histamine binding IMP
IMP: 通过突变表型推断
7678492 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemical synaptic transmission IDA
IDA: 通过直接分析推断
12419527 RGD
involved in negative regulation of steroid biosynthetic process IMP
IMP: 通过突变表型推断
15917347 RGD
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
12419527 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
17169617 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
18607976 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hrh1 蛋白结构

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (84 - 533)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (84 - 110)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (117 - 143)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (155 - 185)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (197 - 218)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (242 - 271)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (462 - 492)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (501 - 526)

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  • 500
  • 542 a.a.
蛋白主名 其他名称

histamine H1 receptor

H1R

HH1R

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hrh1 NCBI NCBI:3269