2. Gene
  3. Il6r - interleukin 6 receptor Gene

Il6r - interleukin 6 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: IL6R1; Il6ra

基因 ID: 24499 | 基因类型: protein coding

关于 Il6r

功能概要

Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach Cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il6r 基因产物(1)

mRNA Protein Name
NM_017020.3 NP_058716.2 interleukin-6 receptor subunit alpha precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in developmental growth IMP
IMP: 通过突变表型推断
23855552 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
19961020 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
7814800 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
15084893 RGD
involved in response to gamma radiation IEP
IEP: 通过表达模式推断
14751512 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
7814800 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
7814800 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
11171594 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
11448096 RGD
located in neuronal cell body membrane IDA
IDA: 通过直接分析推断
8921254 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-6 receptor subunit alpha

IL-6 receptor subunit alpha

IL-6R 1

IL-6R subunit alpha

IL-6R-alpha

IL-6RA

interleukin 6 receptor, alpha

重组 Il6r 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73224 IL-6R Protein, Rat (HEK293, His) NP_058716.2 (L20-P364) ≥95%
HY-P73876 IL-6R Protein, Rat (HEK293, Fc) NP_058716.2 (L20-P364) ≥95%

相关产品

Approval
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P9917 Tocilizumab Antagonist 99.67% 否
HY-P9916 Sarilumab Inhibitor 98.37% 否
Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99702 Levilimab Inhibitor / Phase 3
HY-P99385 Vobarilizumab Inhibitor 97.36% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10284 S7 Antagonist 99.12% 否
HY-RS06777 IL6R Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il6r NCBI NCBI:3570
Mus musculus Il6r NCBI
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