2. Gene
  3. Prkca - protein kinase C, alpha Gene

Prkca - protein kinase C, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C， α

种属: Rattus norvegicus

同用名: Pkca

基因 ID: 24680 | 基因类型: protein coding

关于 Prkca

Primary_assembly 10: 92,894,012-93,288,012 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 26 phenotypes. Biased expression in Muscle (RPKM 146.), Brain (RPKM 14.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动钙依赖性蛋白激酶 C 活性。参与多个过程，包括 ERK1 和 ERK2 级联的正调控；蛋白质磷酸化；和调节囊泡介导的运输。位于几种细胞成分中，包括膜筏；线粒体；和细胞质的核周区。部分含蛋白质复合物。用于研究高血压。脑缺血的生物标志物；充血性心力衰竭;和缺血。该基因的人类直系同源物与扩张型心肌病有关；高级别神经胶质瘤（多发）；大细胞癌；和生殖器官癌（多发性）。与人 PRKCA（蛋白激酶 C α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca 基因产物(1)

mRNA Protein Name
NM_001399299.1 NP_001386228.1 protein kinase C alpha type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9046017 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9514928 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
15272003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in central nervous system neuron axonogenesis IMP
IMP: 通过突变表型推断
18062921 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11562372 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
18073185 RGD
involved in negative regulation of translation IMP
IMP: 通过突变表型推断
16556598 RGD
involved in peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
16717194 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11864993 RGD
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: 通过直接分析推断
11864993 RGD
involved in positive regulation of exocytosis IMP
IMP: 通过突变表型推断
17408632 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
17908462 RGD
involved in positive regulation of synapse assembly IMP
IMP: 通过突变表型推断
18073185 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18972403 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9705215 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
17873323 RGD
involved in response to estradiol IMP
IMP: 通过突变表型推断
18166159 RGD
involved in response to ethanol IMP
IMP: 通过突变表型推断
17408632 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17487266 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17845534 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
17640386 RGD
involved in response to phorbol 13-acetate 12-myristate IDA
IDA: 通过直接分析推断
15272003 RGD
involved in response to reactive oxygen species IMP
IMP: 通过突变表型推断
17905752 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
17728094 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11864993 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11864993 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
11007882 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkca 蛋白结构

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

PKc_like

PKc_like: cl21453 (327 - 717)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
蛋白主名 其他名称

protein kinase C alpha type

PKC-A

PKC-alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11116 PRKCA Human Pre-designed siRNA Set A / 否
HY-RS11117 Prkca Mouse Pre-designed siRNA Set A / 否
HY-RS11118 Prkca Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkca NCBI NCBI:5578
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