2. Gene
  3. Rara - retinoic acid receptor, alpha Gene

Rara - retinoic acid receptor, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：视黄酸受体， α

种属: Rattus norvegicus

基因 ID: 24705 | 基因类型: protein coding

关于 Rara

Primary_assembly 10: 83,893,384-83,928,142 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 331 orthologues, 19 paralogues and is associated with 12 phenotypes. Biased expression in Lung (RPKM 12.3), Kidney (RPKM 75.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动组蛋白脱乙酰酶结合活性；核酸结合活性；和磷脂酰肌醇 3-激酶调节剂活性。参与多个过程，包括动物器官发育；细胞内信号转导的正向调节；和对维生素 A 的反应。位于树突中；核;和细胞质的核周区。肌萎缩侧索硬化的生物标志物。该基因的人类直系同源物与急性早幼粒细胞白血病有关。与人类 RARA（视黄酸受体 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone deacetylase binding activity; nucleic acid binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and response to vitamin A. Located in dendrite; nucleus; and perinuclear region of cytoplasm. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rara 基因产物(1)

mRNA Protein Name
NM_031528.2 NP_113716.2 retinoic acid receptor alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heterocyclic compound binding IDA
IDA: 通过直接分析推断
19100254 RGD
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
21383775 RGD
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
19073915 RGD
enables mRNA regulatory element binding translation repressor activity IDA
IDA: 通过直接分析推断
19073915 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in female pregnancy IEP
IEP: 通过表达模式推断
18342837 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
18619947 RGD
involved in liver development IEP
IEP: 通过表达模式推断
15388488 RGD
involved in male gonad development IDA
IDA: 通过直接分析推断
14613895 RGD
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12704731 RGD
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
19073915 RGD
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
19100254 RGD
involved in prostate gland development IEP
IEP: 通过表达模式推断
12193579 RGD
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
12186877 RGD
involved in regulation of myelination IDA
IDA: 通过直接分析推断
20648638 RGD
involved in regulation of synaptic plasticity IDA
IDA: 通过直接分析推断
18957222 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
17078027 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
12193579 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
12954654 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
18384703 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
19073915 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12193579 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rara 蛋白结构

NR_DBD_RAR

NR_DBD_RAR: cd06964 (81 - 165)

NR_LBD_RAR

NR_LBD_RAR: cd06937 (185 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
蛋白主名 其他名称

retinoic acid receptor alpha

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101106 AR7 Antagonist 99.38% 否
HY-RS11669 RARA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11670 Rara Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11671 Rara Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rara NCBI NCBI:5914
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