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  2. Prkcb - protein kinase C, beta Gene

Prkcb - protein kinase C, beta Gene

中文名称:蛋白激酶 C, β

种属: Rattus norvegicus

同用名: Pkcb; Prkcb1

基因 ID: 25023 | 基因类型: protein coding

关于 Prkcb

Primary_assembly 1: 176,832,226-177,163,536 forward strand.mRatBN7.2:CM026974.1

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 25 phenotypes. Biased expression in Brain (RPKM 562.1), Spleen (RPKM 51.2) and 6 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶 C 活性。参与多种过程,包括二苯并二恶英代谢过程;正调节含牙本质牙的牙发生;和对维生素 D 的反应。位于刷状缘膜;中心体;和胞质溶胶。用于研究高血糖;高血压;和矽肺。充血性心力衰竭的生物标志物;肥胖;和癫痫持续状态。该基因的人类直系同源物与扩张型心肌病和肺非小细胞癌有关。与人 PRKCB(蛋白激酶 C β)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein kinase C activity. Involved in several processes, including dibenzo-p-dioxin metabolic process; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb 基因产物(2)

mRNA Protein Name
NM_012713.4 NP_036845.3 protein kinase C beta type isoform 1
NM_001172305.1 NP_001165776.1 protein kinase C beta type isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7537734 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dibenzo-p-dioxin metabolic process IEP
IEP: 通过表达模式推断
16797713 RGD
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
11714718 RGD
involved in positive regulation of odontogenesis of dentin-containing tooth IEP
IEP: 通过表达模式推断
15763930 RGD
involved in regulation of dopamine secretion IMP
IMP: 通过突变表型推断
15647254 RGD
involved in regulation of growth IMP
IMP: 通过突变表型推断
3345563 RGD
involved in response to angiotensin IDA
IDA: 通过直接分析推断
11507002 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16997974 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
15030177 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
10206343 RGD
involved in response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
15647254 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IDA
IDA: 通过直接分析推断
17272350 RGD
located in centrosome IDA
IDA: 通过直接分析推断
14594954 RGD
located in cytosol IDA
IDA: 通过直接分析推断
11507002 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Prkcb 蛋白结构

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

STKc_cPKC_beta

STKc_cPKC_beta: cd05616 (340 - 662)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
蛋白主名 其他名称

protein kinase C beta type

PKC-beta

protein kinase C beta I

protein kinase C beta II

protein kinase C, beta 1

Prkcb 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Prkcb P68403 Ptpra Mus musculus P18052
Protein Kinase Assay
7537734
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcb NCBI NCBI:5579