PDGFRA - platelet derived growth factor receptor alpha Gene

中文名称：血小板衍生生长因子受体 α

种属: Rattus norvegicus

同用名: APDGFR; PDGFACE

关于 PDGFRA

功能概要

该基因编码的蛋白可启动磷脂酰肌醇 3 激酶结合活性和血小板衍生生长因子 α 受体活性。参与多个过程，包括动物器官发育；细胞对 interleukin-1 的反应；和参与肺形态发生的分支的正调节。位于多个细胞成分中，包括轴突；核;和质膜。用于研究大脑中动脉梗塞。皮肤慢性溃疡生物标志物；高血压;羊水过少;肺纤维化;和坐骨神经病。该基因的人类直系同源物与血液癌症有关（多个）；嗜酸性粒细胞增多症;和胰腺癌。与人 PDGFRA（血小板衍生生长因子受体 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor alpha-receptor activity. Involved in several processes, including animal organ development; cellular response to interleukin-1; and positive regulation of branching involved in lung morphogenesis. Located in several cellular components, including axon; nucleus; and plasma membrane. Used to study middle cerebral artery infarction. Biomarker of chronic ulcer of skin; hypertension; oligohydramnios; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hematologic Cancer (multiple); hypereosinophilic syndrome; and pancreatic Cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]