Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

中文名称：血小板衍生生长因子受体， α多肽

种属: Mus musculus

同用名: CD140a; Pdgfr-2

关于 Pdgfra

功能概要

该基因编码受体酪氨酸激酶蛋白家族的成员。血小板衍生生长因子蛋白配体与该受体的结合会触发受体二聚化和自身磷酸化，从而激活多个下游信号通路。通过编码受体的信号在原肠胚形成和几乎所有器官系统的发育中发挥作用。据报道，缺少该基因功能拷贝的小鼠会出现肺、骨骼、睾丸和中枢神经系统缺陷，并在出生后不久死亡。基因转录物的选择性剪接和内含子聚腺苷酸化与成年小鼠的肌肉再生和纤维化有关。 [RefSeq 提供，2017 年 1 月]

This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]