Alox5 - arachidonate 5-lipoxygenase Gene

中文名称：花生四烯酸 5-脂氧合酶

种属: Rattus norvegicus

同用名: LOX5A

关于 Alox5

功能概要

预计该基因编码的蛋白可启动花生四烯酸 5-脂氧合酶活性和铁离子结合活性。参与多个过程，包括细胞色素-c 氧化酶活性的正调节；血管收缩的正向调节；和对高氧的反应。位于多个细胞成分中，包括树突；核包膜；和肌膜。用于研究多种疾病，包括脑缺血；高血压（多发性）；胸膜炎;门静脉高压症;和肺水肿。肺动脉高压的生物标志物。该基因的人类直系同源物与动脉疾病有关（多个）；哮喘（多发）；胰腺癌;和肺结核。与人类 ALOX5（花生四烯酸 5-脂氧合酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in several processes, including positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; and response to hyperoxia. Located in several cellular components, including dendrite; nuclear envelope; and sarcolemma. Used to study several diseases, including brain ischemia; hypertension (multiple); pleurisy; portal hypertension; and pulmonary edema. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]