2. Gene
  3. Slc2a2 - solute carrier family 2 member 2 Gene

Slc2a2 - solute carrier family 2 member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 2 成员 2

种属: Rattus norvegicus

同用名: GTT2; Glut2

基因 ID: 25351 | 基因类型: protein coding

关于 Slc2a2

Primary_assembly 2: 111,611,774-111,639,933 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 312 orthologues, 12 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 1233.6) and Kidney (RPKM 253.5).

功能概要

该基因编码的蛋白可启动 D-葡萄糖跨膜转运蛋白活性；脱氢抗坏血酸跨膜转运蛋白活性；和胰岛素受体结合活性。涉及多个过程，包括碳水化合物的利用；脱氢抗坏血酸转运；和己糖跨膜转运。位于几种细胞成分中，包括顶端质膜；基底外侧质膜；和刷状缘膜。该基因的人类直系同源物与 Fanconi 综合征有关；糖原贮积病；和 2 型糖尿病。与人类 SLC2A2（溶质载体家族 2 成员 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and Insulin Receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a2 基因产物(1)

mRNA Protein Name
NM_012879.2 NP_037011.2 solute carrier family 2, facilitated glucose transporter member 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-glucose transmembrane transporter activity IDA
IDA: 通过直接分析推断
3048704 RGD
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
18668520 RGD
enables insulin receptor binding IPI
IPI: 通过物理相互作用推断
15665515 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
3048704 RGD
involved in D-glucose transmembrane transport IEP
IEP: 通过表达模式推断
12095416 RGD
involved in carbohydrate utilization IMP
IMP: 通过突变表型推断
11834736 RGD
involved in cellular response to fatty acid IDA
IDA: 通过直接分析推断
27568038 RGD
involved in cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
27568038 RGD
involved in dehydroascorbic acid transport IDA
IDA: 通过直接分析推断
18668520 RGD
involved in fructose transmembrane transport IEP
IEP: 通过表达模式推断
12095416 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
12095416 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
12095416 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11325341 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
1468587 RGD
located in brush border IDA
IDA: 通过直接分析推断
12095416 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
17272350 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
18668520 RGD
located in endosome IDA
IDA: 通过直接分析推断
15665515 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
3048704 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc2a2 蛋白结构

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (11 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
蛋白主名 其他名称

solute carrier family 2, facilitated glucose transporter member 2

GLUT-2

glucose transporter type 2, liver

solute carrier family 2 (facilitated glucose transporter), member 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13164 SLC2A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13165 Slc2a2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13166 Slc2a2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc2a2 NCBI NCBI:6514
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