LCLAT1 - lysocardiolipin acyltransferase 1 Gene

中文名称：溶血心磷脂酰基转移酶 1

种属: Homo sapiens

同用名: LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849

基因 ID: 253558 | 基因类型: protein coding

关于 LCLAT1

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:30,447,246-30,644,225 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues.

功能概要

启用 1-acylglycerol-3-phosphate O-acyltransferase 活性。预计参与磷脂酰肌醇酰基链重塑。位于胞质溶胶和内质网中。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

LCLAT1 基因产物(4)

mRNA	Protein	Name
NM_001002257.3	NP_001002257.1	lysocardiolipin acyltransferase 1 isoform 2
NM_001304445.2	NP_001291374.1	lysocardiolipin acyltransferase 1 isoform 2
NM_001304446.2	NP_001291375.1	lysocardiolipin acyltransferase 1 isoform 3
NM_182551.5	NP_872357.2	lysocardiolipin acyltransferase 1 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: 通过直接分析推断	16620771	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	16620771	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LCLAT1 蛋白结构

Acyltransferase

0
100
200
300
414 a.a.

蛋白主名

其他名称

lysocardiolipin acyltransferase 1

1-AGP acyltransferase 8

LCLAT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LCLAT1	Q6UWP7	GOPC	Homo sapiens	Q9HD26	Validated Y2H	25416956
种属内	LCLAT1	Q6UWP7	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
种属内	LCLAT1	Q6UWP7	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
种属内	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	LCLAT1	Q6UWP7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Mitochondrial Trifunctional Protein Deficiency

Tfp Deficiency	MTPD
Trifunctional Protein Deficiency	Trifunctional Protein Deficiency With Myopathy And Neuropathy
Tfpd	Familial Hypertrophic Cardiomyopathy
Cardiomyopathy Familial Hypertrophic	Familial Hcm
Heritable Hypertrophic Cardiomyopathy	Mtp Deficiency
Tpa Deficiency	Trifunctional Protein Deficiency, Type 2
Abetalipoproteinemia

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07551	LCLAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	LCLAT1	VGNC	VGNC:107213
Rattus norvegicus	LCLAT1	RGD	RGD:1565906
Felis catus	LCLAT1	VGNC	VGNC:81111
Bos taurus	LCLAT1	VGNC	VGNC:30811
Canis familiaris	LCLAT1	VGNC	VGNC:42608
Mus musculus	LCLAT1	MGD	MGI:2684937

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LCLAT1 - lysocardiolipin acyltransferase 1 Gene

关于 LCLAT1

功能概要

LCLAT1 基因产物(4)

LCLAT1 蛋白结构

LCLAT1 蛋白互作信息

关联疾病

直系同源

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LCLAT1 - lysocardiolipin acyltransferase 1 Gene

关于 LCLAT1

功能概要

LCLAT1 基因产物(4)

LCLAT1 蛋白结构

LCLAT1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z