2. Gene
  3. Faslg - Fas ligand Gene

Faslg - Fas ligand Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1

基因 ID: 25385 | 基因类型: protein coding

关于 Faslg

功能概要

Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic Cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]

Faslg 基因产物(1)

mRNA Protein Name
NM_012908.1 NP_037040.1 tumor necrosis factor ligand superfamily member 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables death receptor binding IPI
IPI: 通过物理相互作用推断
15557468 RGD
enables tumor necrosis factor receptor binding IMP
IMP: 通过突变表型推断
16154149 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
10029626 RGD
involved in endosomal lumen acidification IDA
IDA: 通过直接分析推断
18045865 RGD
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
16689665 RGD
involved in inflammatory cell apoptotic process IGI
IGI: 通过遗传相互作用推断
16154149 RGD
involved in intracellular chloride ion homeostasis IDA
IDA: 通过直接分析推断
18045865 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
18471522 RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18471522 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
9858598 RGD
involved in response to growth factor IEP
IEP: 通过表达模式推断
18692025 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17899301 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
15541714 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16563377 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 6

Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)

CD95 ligand

CD95L protein

Fas antigen ligand

Fas ligand (TNF superfamily, member 6)

Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)

重组 Faslg 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74156 Fas Ligand Protein, Rat (P.pastoris, His) P36940 (L104-L278) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99445 Asunercept Inhibitor 98.13% Phase 3
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04752 FASLG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Faslg NCBI NCBI:356
Mus musculus Faslg NCBI
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