Camk2a - calcium/calmodulin-dependent protein kinase II alpha Gene

中文名称：钙/钙调蛋白依赖性蛋白激酶 II α

种属: Rattus norvegicus

同用名: PKCCD; PK2CDD

关于 Camk2a

功能概要

该基因编码的蛋白可启动 GTPase 激活蛋白结合活性和钙调蛋白依赖性蛋白激酶活性。参与多个过程，包括NMDA选择性谷氨酸受体信号通路；蛋白质磷酸化；和调节蛋白质在细胞外周的定位。位于几种细胞成分中，包括树突细胞质；谷氨酸能突触后密度；和神经细胞体。在多种细胞成分中具有活性，包括谷氨酸能突触；突触后细胞质；和突触前细胞质。大脑中动脉梗死和短暂性脑缺血的生物标志物。该基因的人类直系同源基因与常染色体显性智力低下 53 和常染色体隐性非综合征性智力障碍有关。与人 CAMK2A（钙/钙调蛋白依赖性蛋白激酶 II α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activating protein binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; protein phosphorylation; and regulation of protein localization to cell periphery. Located in several cellular components, including dendrite cytoplasm; glutamatergic postsynaptic density; and neuronal cell body. Is active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/Calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Apr 2022]