1. Gene
  2. Ctsc - cathepsin C Gene

Ctsc - cathepsin C Gene

中文名称:组织蛋白酶 C

种属: Rattus norvegicus

同用名: CATC; DPPI; DPP-I

基因 ID: 25423 | 基因类型: protein coding

关于 Ctsc

Primary_assembly 1: 142,028,392-142,060,387 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 233 orthologues, 27 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 64.8), Kidney (RPKM 269.7) and 7 other tissues.

功能概要

该基因编码的蛋白可启动多项功能,包括伴侣绑定活动;氯离子结合活性;和相同的蛋白质结合活性。涉及多个过程,包括老化;参与细胞蛋白质分解代谢过程的蛋白水解的正调节;和蛋白水解。位于高尔基体;内质网;和溶酶体。脑缺血的生物标志物;高血压;和肥胖。该基因的人类直系同源物与 Papillon-Lefevre 病和侵袭性牙周炎有关。与人类 CTSC(组织蛋白酶 C)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in several processes, including aging; positive regulation of proteolysis involved in cellular protein catabolic process; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (Cathepsin C). [provided by Alliance of Genome Resources, Apr 2022]

Ctsc 基因产物(2)

mRNA Protein Name
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride ion binding IDA
IDA: 通过直接分析推断
11602245 RGD
enables identical protein binding IDA
IDA: 通过直接分析推断
11602245 RGD
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
18307834 RGD
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
18307834 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of proteolysis involved in protein catabolic process IDA
IDA: 通过直接分析推断
18307834 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosome IDA
IDA: 通过直接分析推断
18307834 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ctsc 蛋白结构

CathepsinC_exc

CathepsinC_exc: pfam08773 (24 - 137)

Pox_I6

Pox_I6: cl28439 (167 - 203)

Peptidase_C1A_CathepsinC

Peptidase_C1A_CathepsinC: cd02621 (229 - 458)

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  • 462 a.a.
蛋白主名 其他名称

dipeptidyl peptidase 1

cathepsin J

dipeptidyl peptidase I

dipeptidyl transferase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctsc NCBI NCBI:1075
Mus musculus Ctsc NCBI NCBI:13032