MCM9 - minichromosome maintenance 9 homologous recombination repair factor Gene

中文名称：微染色体维持 9 同源重组修复因子

种属: Homo sapiens

同用名: ODG4; MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3

基因 ID: 254394 | 基因类型: protein coding

关于 MCM9

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:118,813,455-118,935,159 (from NCBI)

This gene has 9 transcripts (splice variants), 171 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 3.1), lymph node (RPKM 3.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是微型染色体维护 (MCM) 蛋白质家族的成员，该家族对于启动真核基因组复制至关重要。这种蛋白质与染色质的结合已被证明是将 MCM2-7 解旋酶募集到 DNA 复制起点的先决条件。这种蛋白质还结合染色质许可和 DNA 复制因子 1，CDT1，并且是正调节因子。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

MCM9 基因产物(19)

mRNA	Protein	Name
NM_001378356.1	NP_001365285.1	DNA helicase MCM9 isoform 1
NM_001378357.1	NP_001365286.1	DNA helicase MCM9 isoform 1
NM_001378358.1	NP_001365287.1	DNA helicase MCM9 isoform 2
NM_001378359.1	NP_001365288.1	DNA helicase MCM9 isoform 3
NM_001378360.1	NP_001365289.1	DNA helicase MCM9 isoform 3
NM_001378361.1	NP_001365290.1	DNA helicase MCM9 isoform 4
NM_001378362.1	NP_001365291.1	DNA helicase MCM9 isoform 4
NM_001378363.1	NP_001365292.1	DNA helicase MCM9 isoform 4
NM_001378364.1	NP_001365293.1	DNA helicase MCM9 isoform 5
NM_001378365.1	NP_001365294.1	DNA helicase MCM9 isoform 6
NM_001378366.1	NP_001365295.1	DNA helicase MCM9 isoform 7
NM_001378367.1	NP_001365296.1	DNA helicase MCM9 isoform 8
NM_001378368.1	NP_001365297.1	DNA helicase MCM9 isoform 9
NM_001378369.1	NP_001365298.1	DNA helicase MCM9 isoform 10
NM_001378370.1	NP_001365299.1	DNA helicase MCM9 isoform 11
NM_001378371.1	NP_001365300.1	DNA helicase MCM9 isoform 12
NM_001378372.1	NP_001365301.1	DNA helicase MCM9 isoform 13
NM_017696.3	NP_060166.2	DNA helicase MCM9 isoform 1
NM_153255.5	NP_694987.1	DNA helicase MCM9 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA helicase activity	IMP IMP: 通过突变表型推断	26300262	GOA
enables MutLbeta complex binding	IDA IDA: 通过直接分析推断	26300262	GOA
enables MutSalpha complex binding	IDA IDA: 通过直接分析推断	26300262	GOA
enables MutSbeta complex binding	IDA IDA: 通过直接分析推断	26300262	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	23401855	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	23401855	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23401855	GOA
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	26215093	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	22771115	GOA
involved in DNA duplex unwinding	IDA IDA: 通过直接分析推断	26300262	GOA
involved in DNA duplex unwinding	IMP IMP: 通过突变表型推断	26300262	GOA
NOT involved in DNA replication	IGI IGI: 通过遗传相互作用推断	23401855	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	22771115	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: 通过突变表型推断	23401855	GOA
involved in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	IMP IMP: 通过突变表型推断	26300262	GOA
involved in protein localization to chromatin	IMP IMP: 通过突变表型推断	23401855	GOA
involved in recombinational interstrand cross-link repair	IMP IMP: 通过突变表型推断	23401855	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MCM8-MCM9 complex	IDA IDA: 通过直接分析推断	22771115	GOA
part of MCM8-MCM9 complex	IPI IPI: 通过物理相互作用推断	26300262	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23401855	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCM9 蛋白结构

MCM

0
200
400
600
800
1000
1143 a.a.

蛋白主名

其他名称

DNA helicase MCM9

DNA replication licensing factor MCM9

MCM9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MCM9	Q9NXL9	MSH6	Homo sapiens	P52701	Anti Bait CoIP	26300262
种属内	MCM9	Q9NXL9	MSH6	Homo sapiens	P52701	Anti Tag CoIP	26300262
种属内	MCM9	Q9NXL9	MLH1	Homo sapiens	P40692	Anti Bait CoIP	26300262
种属内	MCM9	Q9NXL9	MLH1	Homo sapiens	P40692	Anti Tag CoIP	26300262
种属内	MCM9	Q9NXL9	MCM8	Homo sapiens	Q9UJA3	Anti Tag CoIP	26300262
种属内	MCM9	Q9NXL9	MCM8	Homo sapiens	Q9UJA3	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ovarian Dysgenesis 4

46,Xx Ovarian Dysgenesis-Short Stature Syndrome	ODG4
Dysgenesis, Ovarian, Type 4

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Uterine Hypoplasia

Endometrial Mixed Adenocarcinoma

Amenorrhea

Absence Of Menstruation

Amenia

Nondisjunction

Mosaicism, Chromosomal

Mixoploidy, Familial

Meier-Gorlin Syndrome 8

MGORS8

Deafness, Autosomal Dominant 70

DFNA70	Autosomal Dominant Nonsyndromic Deafness 70
Autosomal Dominant Deafness 70	Deafness, Autosomal Dominant, 70

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08242	MCM9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MCM9	MGD	MGI:1918817
Canis familiaris	MCM9	VGNC	VGNC:43089
Bos taurus	MCM9	VGNC	VGNC:31315
Rattus norvegicus	MCM9	RGD	RGD:1560557
Macaca mulatta	MCM9	VGNC	VGNC:83432
Felis catus	MCM9	VGNC	VGNC:63415

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MCM9 - minichromosome maintenance 9 homologous recombination repair factor Gene

关于 MCM9

功能概要

MCM9 基因产物(19)

MCM9 蛋白结构

MCM9 蛋白互作信息

关联疾病

直系同源

热门区域

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MCM9 - minichromosome maintenance 9 homologous recombination repair factor Gene

关于 MCM9

功能概要

MCM9 基因产物(19)

MCM9 蛋白结构

MCM9 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z