1. Gene
  2. Hrh2 - histamine receptor H 2 Gene

Hrh2 - histamine receptor H 2 Gene

中文名称:组胺受体H 2

种属: Rattus norvegicus

同用名: H2R; HH2R

基因 ID: 25461 | 基因类型: protein coding

关于 Hrh2

Primary_assembly 17: 10,368,298-10,407,631 reverse strand.mRatBN7.2:CM026990.1

This gene has 1 transcript (splice variant), 249 orthologues, 35 paralogues and is associated with 11 phenotypes. Biased expression in Brain (RPKM 17.7), Spleen (RPKM 8.2) and 7 other tissues.

功能概要

该基因编码的蛋白可启动杂环化合物结合活性和组胺受体活性。参与细胞对组胺的反应和花生四烯酸分泌的负调节。位于膜内。短暂性脑缺血的生物标志物。与人类 HRH2(组胺受体 H2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables heterocyclic compound binding activity and Histamine Receptor activity. Involved in cellular response to histamine and negative regulation of arachidonic acid secretion. Located in membrane. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (Histamine Receptor H2). [provided by Alliance of Genome Resources, Apr 2022]

Hrh2 基因产物(1)

mRNA Protein Name
NM_001413011.1 NP_001399940.1 histamine H2 receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heterocyclic compound binding IDA
IDA: 通过直接分析推断
1313563 RGD
enables histamine receptor activity IDA
IDA: 通过直接分析推断
1313563 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to histamine IEP
IEP: 通过表达模式推断
1313563 RGD
involved in negative regulation of arachidonate secretion IDA
IDA: 通过直接分析推断
1313563 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hrh2 蛋白结构

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (18 - 297)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (19 - 45)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (52 - 79)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (90 - 120)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (132 - 152)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (177 - 207)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (225 - 255)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (265 - 290)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
蛋白主名 其他名称

histamine H2 receptor

gastric receptor I

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hrh2 NCBI NCBI:3274