2. Gene
  3. Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 cAMP 激活的催化亚基 alpha

种属: Rattus norvegicus

同用名: PKCA1; Cs-PKA

基因 ID: 25636 | 基因类型: protein coding

关于 Prkaca

Primary_assembly 19: 24,155,090-24,178,430 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 289 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 789.1), Adrenal (RPKM 386.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 cAMP 依赖性蛋白激酶活性；蛋白激酶结合活性；和小的 GTPase 结合活性。涉及多个过程，包括昼夜节律睡眠/觉醒周期、REM 睡眠；调节谷氨酸能突触传递；和神经递质的自发胞吐作用。位于多种细胞成分中，包括高尔基体；细胞质的核周区；和突触前。 cAMP 依赖性蛋白激酶复合物的一部分。脑缺血的生物标志物。该基因的人类直系同源物与肾上腺皮质腺瘤有关；充血性心力衰竭;和原发性色素性结节性肾上腺皮质疾病。与人 PRKACA（蛋白激酶 cAMP 激活的催化亚基 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including circadian sleep/wake cycle, REM sleep; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and presynapse. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkaca 基因产物(1)

mRNA Protein Name
NM_001100922.2 NP_001094392.1 cAMP-dependent protein kinase catalytic subunit alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP-dependent protein kinase activity IDA
IDA: 通过直接分析推断
11907174 RGD
enables cAMP-dependent protein kinase activity IMP
IMP: 通过突变表型推断
17190793 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18381233 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11035810 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12672265 RGD
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
23419316 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of meiotic cell cycle IDA
IDA: 通过直接分析推断
16816331 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
15546918 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
17190793 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23349233 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11907174 RGD
involved in regulation of cellular respiration IDA
IDA: 通过直接分析推断
12562968 RGD
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
12562968 RGD
involved in spontaneous exocytosis of neurotransmitter IMP
IMP: 通过突变表型推断
17190793 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cAMP-dependent protein kinase complex IDA
IDA: 通过直接分析推断
11907174 RGD
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
11716788 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
18550536 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
11716788 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
11716788 RGD
located in presynapse IMP
IMP: 通过突变表型推断
17190793 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
12672265 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkaca 蛋白结构

STKc_PKA

STKc_PKA: cd14209 (41 - 330)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha

cAMP-dependent protein kinase catalytic subunit C alpha

protein kinase A

protein kinase, cAMP-dependent, alpha catalytic subunit

protein kinase, cAMP-dependent, catalytic, alpha

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153967 BLU0588 Inhibitor 95.92% 否
HY-150076 BLU2864 Inhibitor 99.24% 否
HY-150072 DS89002333 Inhibitor 99.87% 否
HY-150072B (R)-DS89002333 Control 98.74% 否
HY-RS11104 PRKACA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-150072A (2S,4R)-DS89002333 Control / 否
HY-150073 DS01080522 Inhibitor / 否
HY-RS11105 Prkaca Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11106 Prkaca Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkaca NCBI NCBI:5566
Canis familiaris Prkaca NCBI NCBI:403556
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