Cckbr - cholecystokinin B receptor Gene

中文名称：胆囊收缩素B受体

种属: Rattus norvegicus

同用名: Cck2r; Cholrec

关于 Cckbr

功能概要

缩胆囊素是最早在哺乳动物大脑中发现的胃肠肽之一。胆囊收缩素受体是 G 蛋白偶联受体超家族的成员，可刺激磷脂酰肌醇更新和细胞内钙动员。该基因编码 B 亚型的胆囊收缩素受体。这些受体存在于整个中枢神经系统中，在那里它们调节焦虑、镇痛、觉醒和抗精神病活性。 [RefSeq 提供，2008 年 7 月]

Cholecystokinin was one of the first gastrointestinal Peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a Cholecystokinin Receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008]