Ppara - peroxisome proliferator activated receptor alpha Gene

中文名称：过氧化物酶体增殖物激活受体 α

种属: Rattus norvegicus

同用名: PPAR

关于 Ppara

功能概要

该基因编码的蛋白可启动多种功能，包括 MDM2/MDM4 家族蛋白结合活性； NFAT 蛋白结合活性；和核受体活性。涉及多个过程，包括对尼古丁的行为反应；参与心肌细胞发育的细胞生长的负调节；和对乙醇的反应。位于核内。用于研究肝细胞癌；高血压;高血压脑病;和牙周炎。酒精性肝炎的生物标志物；脂肪肝病；脑积水;和高血压。该基因的人类直系同源物与阿尔茨海默病有关；冠状动脉疾病;肝细胞癌；脂质代谢紊乱；和心肌梗塞。与人 PPARA（过氧化物酶体增殖物激活受体 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]