1. Gene
  2. Ppara - peroxisome proliferator activated receptor alpha Gene

Ppara - peroxisome proliferator activated receptor alpha Gene

中文名称:过氧化物酶体增殖物激活受体 α

种属: Rattus norvegicus

同用名: PPAR

基因 ID: 25747 | 基因类型: protein coding

关于 Ppara

Primary_assembly 7: 116,832,756-116,895,346 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 455 orthologues, 19 paralogues and is associated with 61 phenotypes. Biased expression in Liver (RPKM 134.1), Kidney (RPKM 127.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能,包括 MDM2/MDM4 家族蛋白结合活性; NFAT 蛋白结合活性;和核受体活性。涉及多个过程,包括对尼古丁的行为反应;参与心肌细胞发育的细胞生长的负调节;和对乙醇的反应。位于核内。用于研究肝细胞癌;高血压;高血压脑病;和牙周炎。酒精性肝炎的生物标志物;脂肪肝病;脑积水;和高血压。该基因的人类直系同源物与阿尔茨海默病有关;冠状动脉疾病;肝细胞癌;脂质代谢紊乱;和心肌梗塞。与人 PPARA(过氧化物酶体增殖物激活受体 α)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara 基因产物(1)

mRNA Protein Name
NM_013196.2 NP_037328.1 peroxisome proliferator-activated receptor alpha
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15661831 RGD
enables MDM2/MDM4 family protein binding IPI
IPI: 通过物理相互作用推断
19103650 RGD
enables NFAT protein binding IPI
IPI: 通过物理相互作用推断
22198280 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: 通过物理相互作用推断
28821620 RGD
enables nuclear receptor activity IMP
IMP: 通过突变表型推断
12189208 RGD
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
8910358 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15051727 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
12189208 RGD
enables protein-containing complex binding IMP
IMP: 通过突变表型推断
20132223 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12189208 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16280383 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
22464285 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to nicotine IDA
IDA: 通过直接分析推断
20801430 RGD
involved in cellular response to fructose stimulus IEP
IEP: 通过表达模式推断
11934685 RGD
involved in fatty acid metabolic process IMP
IMP: 通过突变表型推断
12600885 RGD
involved in heart development IEP
IEP: 通过表达模式推断
15754086 RGD
involved in lipoprotein metabolic process IMP
IMP: 通过突变表型推断
15537571 RGD
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
15967866 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
22198280 RGD
involved in nitric oxide metabolic process IEP
IEP: 通过表达模式推断
31489946 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12189208 RGD
involved in regulation of lipid storage IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
27939985 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
15292030 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
33310031 RGD
involved in response to insulin IMP
IMP: 通过突变表型推断
16183630 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
33310031 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
27939985 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ppara 蛋白结构

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (237 - 320)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (337 - 603)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor alpha

PPAR-alpha

nuclear receptor subfamily 1 group C member 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ppara NCBI NCBI:5465
Mus musculus Ppara NCBI NCBI:19013