1. Gene
  2. Ppara - peroxisome proliferator activated receptor alpha Gene

Ppara - peroxisome proliferator activated receptor alpha Gene

中文名称:过氧化物酶体增殖物激活受体 α

种属: Mus musculus

同用名: Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik

基因 ID: 19013 | 基因类型: protein coding

关于 Ppara

Chromosome 15: 85,619,184-85,687,020 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 455 orthologues, 19 paralogues and is associated with 52 phenotypes. Broad expression in liver adult (RPKM 11.2), kidney adult (RPKM 8.7) and 15 other tissues.

功能概要

该基因编码的蛋白可启动多种功能,包括 DNA 结合转录因子活性; RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性;和脂质结合活性。涉及多个过程,包括食欲的负调节;脂肪酸氧化的正调节;和基因表达的调控。作用于几个过程的上游或内部,包括牙釉质矿化;细胞生物合成过程的正调控;和伤口愈合。预测位于核质中。以多种结构表达,包括脂肪组织;早孕;心;肝;和卵母细胞。用于研究糖尿病。该基因的人类直系同源物与阿尔茨海默病有关;冠状动脉疾病;肝细胞癌;脂质代谢紊乱;和心肌梗塞。与人 PPARA(过氧化物酶体增殖物激活受体 α)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lipid binding activity. Involved in several processes, including negative regulation of appetite; positive regulation of fatty acid oxidation; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of cellular biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara 基因产物(2)

mRNA Protein Name
NM_001113418.1 NP_001106889.1 peroxisome proliferator-activated receptor alpha
NM_011144.6 NP_035274.2 peroxisome proliferator-activated receptor alpha
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
16271724 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12015306 MGI
enables lipid binding IDA
IDA: 通过直接分析推断
12955147 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9325263 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16271724 MGI
enables signaling receptor activity IDA
IDA: 通过直接分析推断
12802337 MGI
enables transcription factor binding IDA
IDA: 通过直接分析推断
15232616 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IMP
IMP: 通过突变表型推断
23209793 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
20159955 MGI
acts upstream of or within enamel mineralization IMP
IMP: 通过突变表型推断
19320717 MGI
acts upstream of or within epidermis development IMP
IMP: 通过突变表型推断
12485431 MGI
acts upstream of or within fatty acid metabolic process IMP
IMP: 通过突变表型推断
9488698 MGI
acts upstream of gluconeogenesis IMP
IMP: 通过突变表型推断
15232616 MGI
involved in negative regulation of appetite IMP
IMP: 通过突变表型推断
12955147 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15007068 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12955147 MGI
involved in positive regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
15639194 MGI
acts upstream of or within positive regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
15232616 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8041794 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20385772 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16571721 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23209793 MGI
involved in regulation of circadian rhythm IDA
IDA: 通过直接分析推断
20159955 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
15313227 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
11514592 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ppara 蛋白结构

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (100 - 183)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (200 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor alpha

nuclear receptor subfamily 1 group C member 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ppara NCBI NCBI:5465