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  2. DCAF12 - DDB1 and CUL4 associated factor 12 Gene

DCAF12 - DDB1 and CUL4 associated factor 12 Gene

中文名称:DDB1 和 CUL4 相关因子 12

种属: Homo sapiens

同用名: CT102; TCC52; WDR40A; KIAA1892

基因 ID: 25853 | 基因类型: protein coding

关于 DCAF12

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,086,387-34,126,698 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 2 paralogues. Broad expression in testis (RPKM 38.2), lymph node (RPKM 19.3) and 25 other tissues.

功能概要

该基因编码一种含有 WD 重复序列的蛋白质,该蛋白质与 COP9 信号体相互作用,COP9 信号体是一种大分子复合物,可与 cullin-RING E3 连接酶相互作用并通过水解 cullin-Nedd8 结合物来调节其活性。[RefSeq 提供,2009 年 7 月]

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 Ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

DCAF12 基因产物(1)

mRNA Protein Name
NM_015397.4 NP_056212.1 DDB1- and CUL4-associated factor 12
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16949367 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
29779948 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IDA
IDA: 通过直接分析推断
34065512 GOA
acts upstream of regulation of autophagy IDA
IDA: 通过直接分析推断
31267705 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: 通过直接分析推断
29779948 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
29779948 GOA
part of Cul4-RING E3 ubiquitin ligase complex IMP
IMP: 通过突变表型推断
16949367 GOA
located in centrosome IDA
IDA: 通过直接分析推断
18957058 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
34065512 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18957058 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
34065512 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DCAF12 蛋白结构

WD40

WD40: WD domain, G-beta repeat (181 - 211)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

DDB1- and CUL4-associated factor 12

WD repeat domain 40A

直系同源

种属 基因名 来源 基因 ID
Felis catus DCAF12 VGNC VGNC:61355
Bos taurus DCAF12 VGNC VGNC:27901
Mus musculus DCAF12 MGD MGI:1916220
Macaca mulatta DCAF12 VGNC VGNC:71678
Rattus norvegicus DCAF12 RGD RGD:1594034
Canis familiaris DCAF12 VGNC VGNC:39790
Others DCAF12 NCBI