2. Gene
  3. NECTIN3 - nectin cell adhesion molecule 3 Gene

NECTIN3 - nectin cell adhesion molecule 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：连接蛋白细胞粘附分子 3

种属: Homo sapiens

同用名: PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3

基因 ID: 25945 | 基因类型: protein coding

关于 NECTIN3

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:111,071,816-111,194,170 (from NCBI)

This gene has 11 transcripts (splice variants), 285 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 22 other tissues.

功能概要

该基因编码连接蛋白家族的一个成员，其在粘附连接处起粘附分子的作用。该家族成员与其他 nectin 样蛋白和 afadin 相互作用，afadin 是一种丝状肌动蛋白结合蛋白，参与定向运动、细胞增殖和存活的调节。该基因在涉及睫状体的眼部发育中发挥作用。该基因的突变被认为会导致先天性眼部缺陷。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with Other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

NECTIN3 基因产物(3)

mRNA Protein Name
NM_001243286.2 NP_001230215.1 nectin-3 isoform 2 precursor
NM_001243288.2 NP_001230217.1 nectin-3 isoform 3
NM_015480.3 NP_056295.1 nectin-3 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
12438620 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22902367 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19011627 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NECTIN3 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (64 - 166)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (175 - 256)

Ig_2

Ig_2: Immunoglobulin domain (287 - 348)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
蛋白主名 其他名称

nectin-3

nectin 3

NECTIN3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NECTIN3 Q9NQS3 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
NECTIN3 Q9NQS3 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
种属内
NECTIN3 Q9NQS3 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
种属内
NECTIN3 Q9NQS3 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
种属内
NECTIN3 Q9NQS3 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
种属内
NECTIN3 Q9NQS3 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
种属内
NECTIN3 Q9NQS3 RGS20 Homo sapiens O76081
Y2H Prey Pooling
25416956
种属内
NECTIN3 Q9NQS3 RGS20 Homo sapiens O76081
Y2H Array
25416956
种属内
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
FACS
12011057
种属内
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
Protein Array
21982860
种属内
NECTIN3 Q9NQS3 NECTIN1 Homo sapiens Q15223
Anti Tag CoIP
33961781
种属内
NECTIN3 Q9NQS3 TIGIT Homo sapiens Q495A1
Protein Array
21982860
种属内
NECTIN3 Q9NQS3 NECTIN2 Homo sapiens Q92692
Anti Tag CoIP
33961781
种属内
NECTIN3 Q9NQS3 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
种属内
NECTIN3 Q9NQS3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NECTIN3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7782 Nectin-3/CD113 Protein, Human (309a.a, HEK293, His) Q9NQS3-1 (G58-P366) ≥95%
HY-P73306 Nectin-3/CD113 Protein, Human (400a.a, HEK293, His) Q9NQS3-1/NP_056295.1(G58-D400) ≥95%
HY-P78180 Nectin-3/CD113 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NQS3-1 (G58-D400) ≥95%
HY-P78496 Nectin-3/CD113 Protein, Human (HEK293, His-Avi) Q9NQS3 (G58-D400) ≥95%

关联疾病

疾病名称 别名
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Clostridium Difficile Colitis

Pseudomembranous Colitis

Colitis Pseudomembranous

Enterocolitis, Pseudomembranous

Pseudomembranous Enterocolitis

Clostridium Difficile Infection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09176 NECTIN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NECTIN3 VGNC VGNC:102787
Rattus norvegicus NECTIN3 RGD RGD:1309516
Mus musculus NECTIN3 MGD MGI:1930171
Macaca mulatta NECTIN3 VGNC VGNC:83928
Bos taurus NECTIN3 VGNC VGNC:106835
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