1. Gene
  2. ADGRA2 - adhesion G protein-coupled receptor A2 Gene

ADGRA2 - adhesion G protein-coupled receptor A2 Gene

中文名称:粘附 G 蛋白偶联受体 A2

种属: Homo sapiens

同用名: TEM5; GPR124

基因 ID: 25960 | 基因类型: protein coding

关于 ADGRA2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,796,883-37,844,896 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 42 paralogues. Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues.

功能概要

预计可启用 G 蛋白偶联受体活性。参与经典 Wnt 信号通路的正调控。 Wnt 信号体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Involved in positive regulation of canonical Wnt signaling pathway. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2022]

ADGRA2 基因产物(1)

mRNA Protein Name
NM_032777.10 NP_116166.9 adhesion G protein-coupled receptor A2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15021905 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
30026314 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Wnt signalosome IDA
IDA: 通过直接分析推断
30026314 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADGRA2 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (88 - 144)

HRM

HRM: Hormone receptor domain (365 - 418)

GPS

GPS: GPCR proteolysis site, GPS, motif (708 - 753)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (780 - 947)

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  • 1338 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor A2

G-protein coupled receptor 124

ADGRA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADGRA2 Q96PE1 DLG1 Homo sapiens Q12959-2 15021905
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Kidney Leiomyosarcoma

Leiomyosarcoma Of Kidney

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect

Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADGRA2 VGNC VGNC:69453
Mus musculus ADGRA2 MGD MGI:1925810
Felis catus ADGRA2 VGNC VGNC:59628
Bos taurus ADGRA2 VGNC VGNC:106631
Rattus norvegicus ADGRA2 RGD RGD:2323365
Canis familiaris ADGRA2 VGNC VGNC:37632