2. Gene
  3. SIPA1L1 - signal induced proliferation associated 1 like 1 Gene

SIPA1L1 - signal induced proliferation associated 1 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号诱导增殖相关 1 样 1

种属: Homo sapiens

同用名: E6TP1; SPAR1

基因 ID: 26037 | 基因类型: protein coding

关于 SIPA1L1

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:71,320,476-71,741,209 (from NCBI)

This gene has 18 transcripts (splice variants), 276 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues.

功能概要

预计启用 GTPase 激活剂活性；肌动蛋白丝结合活性；和蛋白激酶结合活性。预计参与多个过程，包括肌动蛋白细胞骨架组织；激活 GTPase 活性；和突触后组织的调节。位于肌动蛋白细胞骨架和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin Cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin Cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIPA1L1 基因产物(10)

mRNA Protein Name
NM_001284245.3 NP_001271174.1 signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_001284246.2 NP_001271175.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001284247.3 NP_001271176.1 signal-induced proliferation-associated 1-like protein 1 isoform 4
NM_001354285.2 NP_001341214.1 signal-induced proliferation-associated 1-like protein 1 isoform 1
NM_001354286.2 NP_001341215.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354287.2 NP_001341216.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354288.2 NP_001341217.1 signal-induced proliferation-associated 1-like protein 1 isoform 3
NM_001354289.2 NP_001341218.1 signal-induced proliferation-associated 1-like protein 1 isoform 5
NM_001386936.1 NP_001373865.1 signal-induced proliferation-associated 1-like protein 1 isoform 2
NM_015556.4 NP_056371.1 signal-induced proliferation-associated 1-like protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15778465 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIPA1L1 蛋白结构

Rap_GAP

Rap_GAP: Rap/ran-GAP (628 - 816)

SPAR_C

SPAR_C: C-terminal domain of SPAR protein (1504 - 1749)

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  • 1804 a.a.
蛋白主名 其他名称

signal-induced proliferation-associated 1-like protein 1

SIPA1-like protein 1

SIPA1L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SIPA1L1 O43166 SFN Homo sapiens P31947
TAP
15778465
Intra SIPA1L1 O43166 DLG4 Homo sapiens P78352
Y2H Pooling
21653829
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7

Hereditary Nonpolyposis Colorectal Cancer Type 7

Hereditary Non-Polyposis Colorectal Cancer 7

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12929 SIPA1L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SIPA1L1 RGD RGD:708497
Felis catus SIPA1L1 VGNC VGNC:65153
Mus musculus SIPA1L1 MGD MGI:2443679
Canis familiaris SIPA1L1 VGNC VGNC:46180
Bos taurus SIPA1L1 VGNC VGNC:34628
Macaca mulatta SIPA1L1 VGNC VGNC:77284
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