2. Gene
  3. LSM14A - LSM14A mRNA processing body assembly factor Gene

LSM14A - LSM14A mRNA processing body assembly factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LSM14A mRNA 加工体装配因子

种属: Homo sapiens

同用名: RAP55; FAM61A; RAP55A; C19orf13

基因 ID: 26065 | 基因类型: protein coding

关于 LSM14A

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:34,172,504-34,229,288 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 245 orthologues, 1 paralogue and is associated with 62 phenotypes. Ubiquitous expression in thyroid (RPKM 23.9), lymph node (RPKM 21.2) and 25 other tissues.

功能概要

基于与 Sm 蛋白家族的序列同源性，在多种生物体中鉴定出 Sm 样蛋白 (参见 SNRPD2；601061) 。 Sm 样蛋白包含 Sm 序列基序，该基序由 2 个区域组成，该区域由折叠成环的可变长度接头隔开。 Sm 样蛋白被认为形成了存在于 tri-snRNP 颗粒中的稳定异聚体，这对于 pre-mRNA 剪接很重要。[OMIM 提供，2008 年 3 月]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

LSM14A 基因产物(20)

mRNA Protein Name
NM_001114093.3 NP_001107565.1 protein LSM14 homolog A isoform a
NM_001384420.1 NP_001371349.1 protein LSM14 homolog A isoform c
NM_001384421.1 NP_001371350.1 protein LSM14 homolog A isoform d
NM_001384422.1 NP_001371351.1 protein LSM14 homolog A isoform e
NM_001384423.1 NP_001371352.1 protein LSM14 homolog A isoform f
NM_001384424.1 NP_001371353.1 protein LSM14 homolog A isoform g
NM_001384425.1 NP_001371354.1 protein LSM14 homolog A isoform h
NM_001384426.1 NP_001371355.1 protein LSM14 homolog A isoform i
NM_001384427.1 NP_001371356.1 protein LSM14 homolog A isoform j
NM_001384428.1 NP_001371357.1 protein LSM14 homolog A isoform k
NM_001384429.1 NP_001371358.1 protein LSM14 homolog A isoform l
NM_001384430.1 NP_001371359.1 protein LSM14 homolog A isoform m
NM_001384431.1 NP_001371360.1 protein LSM14 homolog A isoform n
NM_001384432.1 NP_001371361.1 protein LSM14 homolog A isoform o
NM_001384433.1 NP_001371362.1 protein LSM14 homolog A isoform o
NM_001384434.1 NP_001371363.1 protein LSM14 homolog A isoform o
NM_001384435.1 NP_001371364.1 protein LSM14 homolog A isoform p
NM_001384436.1 NP_001371365.1 protein LSM14 homolog A isoform q
NM_001384437.1 NP_001371366.1 protein LSM14 homolog A isoform r
NM_015578.4 NP_056393.2 protein LSM14 homolog A isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29510985 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in P-body assembly IDA
IDA: 通过直接分析推断
16484376 GOA
involved in P-body assembly IMP
IMP: 通过突变表型推断
17074753 GOA
involved in mitotic spindle assembly IMP
IMP: 通过突变表型推断
26339800 GOA
involved in negative regulation of translation IMP
IMP: 通过突变表型推断
29510985 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
16484376 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16484376 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
16484376 GOA
located in mitotic spindle IDA
IDA: 通过直接分析推断
26339800 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM14A 蛋白结构

LSM14

LSM14: Scd6-like Sm domain (4 - 97)

FDF

FDF: FDF domain (290 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
蛋白主名 其他名称

protein LSM14 homolog A

LSM14 homolog A

关联疾病

疾病名称 别名
Chromosome 19q13.11 Deletion Syndrome

19q13.11 Microdeletion Syndrome

Monosomy 19q13.11

Del(19)(Q13.11)
Spinal Cord Neuroblastoma

Neuroblastoma Of The Spinal Cord
Spinal Cord Primitive Neuroectodermal Neoplasm

Spinal Cord Pnet

Spinal Cord Primitive Neuroectodermal Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07856 LSM14A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LSM14A VGNC VGNC:42841
Macaca mulatta LSM14A VGNC VGNC:103832
Bos taurus LSM14A VGNC VGNC:31053
Mus musculus LSM14A MGD MGI:1914320
Felis catus LSM14A VGNC VGNC:63322
Rattus norvegicus LSM14A RGD RGD:1305695
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