2. Gene
  3. DCAF4 - DDB1 and CUL4 associated factor 4 Gene

DCAF4 - DDB1 and CUL4 associated factor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DDB1 和 CUL4 相关因子 4

种属: Homo sapiens

同用名: WDR21; WDR21A

基因 ID: 26094 | 基因类型: protein coding

关于 DCAF4

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,926,464-72,962,098 (from NCBI)

This gene has 15 transcripts (splice variants), 89 orthologues and 26 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues.

功能概要

该基因编码一种含有 WD 重复序列的蛋白质，该蛋白质与 Cul4-Ddb1 E3 连接酶大分子复合物相互作用。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2009 年 7 月]

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 Ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF4 基因产物(8)

mRNA Protein Name
NM_001163508.2 NP_001156980.1 DDB1- and CUL4-associated factor 4 isoform 4
NM_001163509.2 NP_001156981.1 DDB1- and CUL4-associated factor 4 isoform 5
NM_001352447.2 NP_001339376.1 DDB1- and CUL4-associated factor 4 isoform 6
NM_001352448.3 NP_001339377.1 DDB1- and CUL4-associated factor 4 isoform 7
NM_001352449.2 NP_001339378.1 DDB1- and CUL4-associated factor 4 isoform 8
NM_015604.4 NP_056419.2 DDB1- and CUL4-associated factor 4 isoform 1
NM_181340.3 NP_851937.1 DDB1- and CUL4-associated factor 4 isoform 2
NM_181341.3 NP_851938.2 DDB1- and CUL4-associated factor 4 isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19966799 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16949367 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCAF4 蛋白结构

WD40

WD40: WD domain, G-beta repeat (368 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
蛋白主名 其他名称

DDB1- and CUL4-associated factor 4

WD repeat domain 21A

DCAF4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
30945288
Intra DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
Intra DCAF4 Q8WV16 DDB1 Homo sapiens Q16531
Anti Tag CoIP
28514442
Intra DCAF4 Q8WV16 ST7 Homo sapiens Q9NRC1
Anti Tag CoIP
30945288
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microphthalmia, Isolated 2

Isolated Microphthalmia 2

MCOP2

Anophthalmia, Clinical, Isolated

Microphthalmia, Isolated, 2

Isolated Clinical Anophthalmia

Microphthalmia, Isolated, Type 2
Atrial Septal Defect 9

ASD9

Atrial Heart Septal Defect 9

Septal Defect, Atrial, Type 9
Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E

Xeroderma Pigmentosum V

Xp Group E

Xp5

Xpe

Xeroderma Pigmentosum, Complementation Group E
Isolated Microphthalmia
Retroperitoneal Leiomyosarcoma
Atrial Septal Defect 5

ASD5

Atrial Heart Septal Defect 5

Septal Defect, Atrial, Type 5
Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03564 DCAF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03565 DCAF4L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DCAF4 RGD RGD:1306241
Canis familiaris DCAF4 VGNC VGNC:50445
Mus musculus DCAF4 MGD MGI:1921078
Macaca mulatta DCAF4 VGNC VGNC:84331
Others DCAF4 NCBI
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