2. Gene
  3. LRRC32 - leucine rich repeat containing 32 Gene

LRRC32 - leucine rich repeat containing 32 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含富含亮氨酸的重复序列 32

种属: Homo sapiens

同用名: GARP; CPPRDD; D11S833E

基因 ID: 2615 | 基因类型: protein coding

关于 LRRC32

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,657,524-76,670,747 (from NCBI)

This gene has 5 transcripts (splice variants), 87 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 24.7), lung (RPKM 19.4) and 23 other tissues.

功能概要

该基因编码一种 I 型膜蛋白，其中包含 20 个富含亮氨酸的重复序列。染色体区域 11q13-11q14 的改变涉及多种病理学。[RefSeq 提供，2008 年 7 月]

This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

LRRC32 基因产物(7)

mRNA Protein Name
NM_001128922.2 NP_001122394.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370187.1 NP_001357116.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370188.1 NP_001357117.1 transforming growth factor beta activator LRRC32 isoform a precursor
NM_001370189.1 NP_001357118.1 transforming growth factor beta activator LRRC32 isoform b
NM_001370190.1 NP_001357119.1 transforming growth factor beta activator LRRC32 isoform c
NM_001370191.1 NP_001357120.1 transforming growth factor beta activator LRRC32 isoform d precursor
NM_005512.3 NP_005503.1 transforming growth factor beta activator LRRC32 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19651619 GOA
enables receptor ligand inhibitor activity IDA
IDA: 通过直接分析推断
22278742 GOA
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
22278742 GOA
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
19651619 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of protein localization to extracellular region IDA
IDA: 通过直接分析推断
19750484 GOA
involved in establishment of protein localization to extracellular region IMP
IMP: 通过突变表型推断
19651619 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
19750484 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19651619 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRRC32 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (22 - 48)

LRR_8

LRR_8: Leucine rich repeat (52 - 109)

LRR_8

LRR_8: Leucine rich repeat (149 - 209)

(219 - 231)

LRR_1

LRR_1: Leucine Rich Repeat (317 - 338)

LRR_8

LRR_8: Leucine rich repeat (365 - 421)

LRR_8

LRR_8: Leucine rich repeat (516 - 573)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
蛋白主名 其他名称

transforming growth factor beta activator LRRC32

garpin

重组 LRRC32 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70419 LRRC32 Protein, Human (HEK293, Fc) Q14392 (H20-N627) ≥95%
HY-P72636 GARP&Latent TGF Beta-1 Complex Protein, Human (HEK293, His, Strep) P01137&Q14392 (L30-S390&H20-N627) ≥95%
HY-P77671 GARP (Y137H)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, Y137H)&P01137 (L30-S390) ≥95%
HY-P77672 GARP (S138G)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, S138G)&P01137 (L30-S390) ≥95%
HY-P77673 GARP (G139N)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, G139N)&P01137 (L30-S390) ≥95%
HY-P77674 GARP&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628)&P01137 (L30-S390) ≥95%
HY-P77675 GARP&Latent TGF beta Complex Protein, Human (Biotinylated, HEK293, His-Avi) Q14392 (H20-L628,GARP)&P01137 (L30-S390,Latent TGF bata 1) ≥95%
HY-P77676 GARP (Mutated)&Latent TGF Beta Complex Protein, Human (HEK293, His-Avi) Q14392 (H20-L628, Y137H, S138G, G139N)&P01137 (L30 ≥95%

关联疾病

疾病名称 别名
Cleft Palate, Proliferative Retinopathy, And Developmental Delay

CPPRDD
Vitreoretinal Degeneration
Vitreoretinopathy
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07815 LRRC32 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LRRC32 VGNC VGNC:63294
Macaca mulatta LRRC32 VGNC VGNC:101300
Canis familiaris LRRC32 VGNC VGNC:59054
Bos taurus LRRC32 VGNC VGNC:54884
Rattus norvegicus LRRC32 RGD RGD:1309087
Mus musculus LRRC32 MGD MGI:93882
Macaca fascicularis LRRC32 NCBI NCBI:102137524
Others LRRC32 NCBI
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