1. Gene
  2. NOC2L - NOC2 like nucleolar associated transcriptional repressor Gene

NOC2L - NOC2 like nucleolar associated transcriptional repressor Gene

中文名称:NOC2 样核仁相关转录抑制因子

种属: Homo sapiens

同用名: NIR; NET7; NET15; PPP1R112

基因 ID: 26155 | 基因类型: protein coding

关于 NOC2L

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:944,203-959,256 (from NCBI)

This gene has 6 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 23.1), skin (RPKM 20.4) and 25 other tissues.

功能概要

组蛋白乙酰转移酶 (HAT) 和组蛋白脱乙酰酶 (HDAC) 对组蛋白进行的修饰可以控制转录调控的主要方面。 NOC2L 代表一种新型的组蛋白乙酰转移酶 (INHAT) 独立于 HDAC 的抑制剂 (Hublitz 等人,2005 [PubMed 16322561]) 。[OMIM 提供,2008 年 3 月]

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of Histone Acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

NOC2L 基因产物(1)

mRNA Protein Name
NM_015658.4 NP_056473.3 nucleolar complex protein 2 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
16322561 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
16322561 GOA
enables histone binding IDA
IDA: 通过直接分析推断
16322561 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
16322561 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16322561 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16322561 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV IDA
IDA: 通过直接分析推断
20959462 GOA
involved in negative regulation of B cell apoptotic process IMP
IMP: 通过突变表型推断
20959462 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16322561 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20123734 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: 通过直接分析推断
16322561 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
20123734 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
20123734 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16322561 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NOC2L 蛋白结构

Noc2

Noc2: Noc2p family (326 - 623)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

nucleolar complex protein 2 homolog

NOC2-like protein

NOC2L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NOC2L Q9Y3T9 TP53 Homo sapiens P04637
Anti Bait CoIP
16322561
种属内
NOC2L Q9Y3T9 TP53 Homo sapiens P04637
Anti Tag CoIP
16322561
种属内
NOC2L Q9Y3T9 TP53 Homo sapiens P04637
Pull Down
16322561
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Epiphyseal Chondrodysplasia, Miura Type

ECDM

Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome

Miura Type Epiphyseal Chondrodysplasia

Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome

Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome

Chondrodysplasia, Epiphyseal, Miura Type

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis

KMIN

Kin

Systemic Karyomegaly

Karyomegalic Tubulointerstitial Nephritis

Ktn

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus NOC2L VGNC VGNC:63845
Bos taurus NOC2L VGNC VGNC:32146
Canis familiaris NOC2L VGNC VGNC:43873
Rattus norvegicus NOC2L RGD RGD:1309387
Mus musculus NOC2L MGD MGI:1931051
Macaca mulatta NOC2L VGNC VGNC:75245