2. Gene
  3. GAS2 - growth arrest specific 2 Gene

GAS2 - growth arrest specific 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长停滞特异性 2

种属: Homo sapiens

同用名: GAS-2

基因 ID: 2620 | 基因类型: protein coding

关于 GAS2

Cytogenetic location: 11p14.3 Genomic coordinates (GRCh38): 11:22,626,002-22,885,695 (from NCBI)

This gene has 11 transcripts (splice variants), 280 orthologues and 7 paralogues. Broad expression in liver (RPKM 2.8), kidney (RPKM 0.9) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种 Caspase-3 底物，在细胞凋亡过程中起到调节微丝和细胞形态变化的作用。它还可以通过抑制钙蛋白酶活性来调节细胞对 p53 依赖性细胞凋亡的易感性。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 5 月]

The protein encoded by this gene is a Caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during Apoptosis. It can also modulate cell susceptibility to p53-dependent Apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]

GAS2 基因产物(9)

mRNA Protein Name
NM_001143830.3 NP_001137302.1 growth arrest-specific protein 2 isoform a
NM_001351224.3 NP_001338153.1 growth arrest-specific protein 2 isoform b
NM_001391933.1 NP_001378862.1 growth arrest-specific protein 2 isoform c
NM_001391934.1 NP_001378863.1 growth arrest-specific protein 2 isoform a
NM_001391935.1 NP_001378864.1 growth arrest-specific protein 2 isoform a
NM_001391936.1 NP_001378865.1 growth arrest-specific protein 2 isoform a
NM_001391937.1 NP_001378866.1 growth arrest-specific protein 2 isoform a
NM_005256.5 NP_005247.1 growth arrest-specific protein 2 isoform a
NM_177553.4 NP_808221.1 growth arrest-specific protein 2 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GAS2 蛋白结构

CH

CH: Calponin homology (CH) domain (38 - 155)

GAS2

GAS2: Growth-Arrest-Specific Protein 2 Domain (200 - 273)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

growth arrest-specific protein 2

关联疾病

疾病名称 别名
Gnathodiaphyseal Dysplasia

GDD

Osteogenesis Imperfecta With Unusual Skeletal Lesions

Gnathodiaphyseal Sclerosis

Osteogenesis Imperfecta, Levin Type

Levin Syndrome 2

Dysplasia, Gnathodiaphyseal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120679 XK469 / 否
HY-RS05282 GAS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05283 GAS2L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05284 GAS2L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GAS2 VGNC VGNC:62467
Macaca mulatta GAS2 VGNC VGNC:72884
Canis familiaris GAS2 VGNC VGNC:41115
Bos taurus GAS2 VGNC VGNC:29257
Rattus norvegicus GAS2 RGD RGD:1563167
Mus musculus GAS2 MGD MGI:95657
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