2. Gene
  3. Map4k1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

Map4k1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 1

种属: Mus musculus

同用名: Hpk1; mHPK1

基因 ID: 26411 | 基因类型: protein coding

关于 Map4k1

Chromosome 7: 28,681,475-28,702,704 forward strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 197 orthologues, 35 paralogues and is associated with 10 phenotypes. Biased expression in spleen adult (RPKM 4.1), thymus adult (RPKM 25.1) and 1 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与细胞内信号转导和蛋白质磷酸化。以多种结构表达，包括消化系统；泌尿生殖系统；淋巴系统；肝;和肺。与人 MAP4K1（丝裂原活化蛋白激酶激酶 kinase kinase 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map4k1 基因产物(2)

mRNA Protein Name
NM_008279.2 NP_032305.2 mitogen-activated protein kinase kinase kinase kinase 1 isoform 1
NM_001355054.1 NP_001341983.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 2

Map4k1 蛋白结构

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 273)

CNH

CNH: smart00036 (505 - 812)

  • 0
  • 200
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  • 600
  • 827 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 1

HPK

MAPK/ERK kinase kinase kinase 1

MEK kinase kinase 1

MEKKK 1

hematopoietic progenitor kinase 1

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138568 HPK1-IN-3 Inhibitor 99.32% 否
HY-138742 HPK1-IN-7 Inhibitor 99.33% 否
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-143868 HPK1-IN-27 Inhibitor / 否
HY-143871 HPK1-IN-30 Inhibitor / 否
HY-156509 HPK1-IN-38 Inhibitor / 否
HY-169199 BAY-405 / 否
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map4k1 NCBI NCBI:11184
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